TY - JOUR
T1 - A population health dietary intervention for African American adults with chronic kidney disease
T2 - The Fruit and Veggies for Kidney Health randomized study
AU - Wesson, Donald E.
AU - Kitzman, Heather
AU - Montgomery, Aisha
AU - Mamun, Abdullah
AU - Parnell, Winfred
AU - Vilayvanh, Brian
AU - Tecson, Kristen M.
AU - Allison, Patricia
N1 - Funding Information:
These studies are supported by NIH grant #R21DK113440 . We are also thankful for the support of the staff of the Baylor Scott & White Health and Wellness Center and Baylor Research Institute .
Funding Information:
This work is being supported by National Institute of Diabetes and Digestive and Kidney Diseases grant “Reducing chronic kidney disease burden in an underserved population” ( R21DK113440 ). Wesson DE, Principle Investigator. NCT03832166.
Funding Information:
This work is being supported by National Institute of Diabetes and Digestive and Kidney Diseases grant ?Reducing chronic kidney disease burden in an underserved population? (R21DK113440). Wesson DE, Principle Investigator. NCT03832166.These studies are supported by NIH grant #R21DK113440. We are also thankful for the support of the staff of the Baylor Scott & White Health and Wellness Center and Baylor Research Institute.
Publisher Copyright:
© 2020 The Authors
PY - 2020/3
Y1 - 2020/3
N2 - Background: Chronic kidney disease (CKD) is commonly asymptomatic until its late stages, reduces life quality and length, is costly to manage, and is disproportionately prevalent in low-income, African American (AA) communities. Traditional health system strategies that engage only patients with symptomatic CKD limit opportunities to prevent progression to end stage kidney disease (ESKD) with the need for expensive kidney replacement therapy and to reduce risk for their major mortality cause, cardiovascular disease (CVD). Published studies show that giving fruits and vegetables (F&V) to AA with early-stage CKD along with preparation instructions slowed CKD progression. This effective, evidenced-based, and potentially scalable dietary intervention might be a component of a community-based strategy to prevent CKD progression. Design: This study supported by NIH grant (R21DK113440) will test the feasibility of an innovative screening strategy conducted at community-based institutions in low-income AA communities and the ability to intervene in individuals identified to have CKD and increased CVD risk with F&V, with or without preparation instructions. Objectives: The study will prospectively compare changes in urine indices predictive of CKD progression and CVD in participants receiving, compared to those not receiving, preparation instructions along with F&V, six months after the intervention. Discussion: Addressing the challenge of increasing progression of early to more advanced stages of CKD with its increased CVD risk requires development of effective strategies to screen, identify, and intervene with individuals found to have CKD with effective, comparatively inexpensive, community-based, and scalable strategies to prevent CKD progression, particularly in low-income, AA communities.
AB - Background: Chronic kidney disease (CKD) is commonly asymptomatic until its late stages, reduces life quality and length, is costly to manage, and is disproportionately prevalent in low-income, African American (AA) communities. Traditional health system strategies that engage only patients with symptomatic CKD limit opportunities to prevent progression to end stage kidney disease (ESKD) with the need for expensive kidney replacement therapy and to reduce risk for their major mortality cause, cardiovascular disease (CVD). Published studies show that giving fruits and vegetables (F&V) to AA with early-stage CKD along with preparation instructions slowed CKD progression. This effective, evidenced-based, and potentially scalable dietary intervention might be a component of a community-based strategy to prevent CKD progression. Design: This study supported by NIH grant (R21DK113440) will test the feasibility of an innovative screening strategy conducted at community-based institutions in low-income AA communities and the ability to intervene in individuals identified to have CKD and increased CVD risk with F&V, with or without preparation instructions. Objectives: The study will prospectively compare changes in urine indices predictive of CKD progression and CVD in participants receiving, compared to those not receiving, preparation instructions along with F&V, six months after the intervention. Discussion: Addressing the challenge of increasing progression of early to more advanced stages of CKD with its increased CVD risk requires development of effective strategies to screen, identify, and intervene with individuals found to have CKD with effective, comparatively inexpensive, community-based, and scalable strategies to prevent CKD progression, particularly in low-income, AA communities.
KW - Albuminuria
KW - Angiotensinogen
KW - Cardiovascular disease
KW - Diet
KW - Glomerular filtration rate
KW - Screening
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U2 - 10.1016/j.conctc.2020.100540
DO - 10.1016/j.conctc.2020.100540
M3 - Article
C2 - 32090186
AN - SCOPUS:85079408758
SN - 2451-8654
VL - 17
JO - Contemporary Clinical Trials Communications
JF - Contemporary Clinical Trials Communications
M1 - 100540
ER -