A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding

Carlo Iavarone, Katrin Ramsauer, Andriy V. Kubarenko, Jason C. Debasitis, Igor Leykin, Alexander N R Weber, Owen M. Siggs, Bruce Beutler, Pu Zhang, Gillis Otten, Ugo D'Oro, Nicholas M. Valiante, M. Lamine Mbow, Alberto Visintin

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Medicine & Life Sciences