A Pilot Randomized Controlled Trial of Docosahexaenoic Acid for the Treatment of Sport-Related Concussion in Adolescents

Shane M. Miller; Aaron J. Zynda; Meagan J. Sabatino; Chanhee Jo; Henry B. Ellis; Robert J Dimeff

doi:10.1177/00099228221101726

A Pilot Randomized Controlled Trial of Docosahexaenoic Acid for the Treatment of Sport-Related Concussion in Adolescents

Shane M. Miller, Aaron J. Zynda, Meagan J. Sabatino, Chanhee Jo, Henry B. Ellis, Robert J Dimeff

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The objective was to examine the use of docosahexaenoic acid (DHA) for the treatment of sport-related concussion (SRC) in adolescent athletes. We hypothesize that participants who intake 2 g of DHA daily will not experience differences in recovery compared with participants who take a placebo. This double-blind, randomized controlled pilot trial was performed in a tertiary pediatric sports medicine clinic from 2013 to 2017 in adolescents (14-18 years) presenting with diagnosed SRC within 4 days of injury. Forty participants were randomized into DHA or PLACEBO group and were instructed to take 2 capsules twice daily for 12 weeks. Participants in the DHA group were symptom-free earlier than the PLACEBO group (11.0 vs 16.0 days, P =.08) and were cleared to begin the Return to Sport progression (14.0 vs 19.5 days, P =.12) sooner. The use of 2 g/day of DHA was well-tolerated and did not significantly affect recovery times in adolescent athletes following SRC. Clinical Trial Registration: ClincalTrials.gov, NCT01903525.

Original language	English (US)
Journal	Clinical Pediatrics
DOIs	https://doi.org/10.1177/00099228221101726
State	Accepted/In press - 2022

Keywords

adolescent
DHA
recovery
sport-related concussion
treatment

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health

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10.1177/00099228221101726

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title = "A Pilot Randomized Controlled Trial of Docosahexaenoic Acid for the Treatment of Sport-Related Concussion in Adolescents",

abstract = "The objective was to examine the use of docosahexaenoic acid (DHA) for the treatment of sport-related concussion (SRC) in adolescent athletes. We hypothesize that participants who intake 2 g of DHA daily will not experience differences in recovery compared with participants who take a placebo. This double-blind, randomized controlled pilot trial was performed in a tertiary pediatric sports medicine clinic from 2013 to 2017 in adolescents (14-18 years) presenting with diagnosed SRC within 4 days of injury. Forty participants were randomized into DHA or PLACEBO group and were instructed to take 2 capsules twice daily for 12 weeks. Participants in the DHA group were symptom-free earlier than the PLACEBO group (11.0 vs 16.0 days, P =.08) and were cleared to begin the Return to Sport progression (14.0 vs 19.5 days, P =.12) sooner. The use of 2 g/day of DHA was well-tolerated and did not significantly affect recovery times in adolescent athletes following SRC. Clinical Trial Registration: ClincalTrials.gov, NCT01903525.",

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AU - Jo, Chanhee

AU - Ellis, Henry B.

AU - Dimeff, Robert J

N1 - Publisher Copyright: © The Author(s) 2022.

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N2 - The objective was to examine the use of docosahexaenoic acid (DHA) for the treatment of sport-related concussion (SRC) in adolescent athletes. We hypothesize that participants who intake 2 g of DHA daily will not experience differences in recovery compared with participants who take a placebo. This double-blind, randomized controlled pilot trial was performed in a tertiary pediatric sports medicine clinic from 2013 to 2017 in adolescents (14-18 years) presenting with diagnosed SRC within 4 days of injury. Forty participants were randomized into DHA or PLACEBO group and were instructed to take 2 capsules twice daily for 12 weeks. Participants in the DHA group were symptom-free earlier than the PLACEBO group (11.0 vs 16.0 days, P =.08) and were cleared to begin the Return to Sport progression (14.0 vs 19.5 days, P =.12) sooner. The use of 2 g/day of DHA was well-tolerated and did not significantly affect recovery times in adolescent athletes following SRC. Clinical Trial Registration: ClincalTrials.gov, NCT01903525.

AB - The objective was to examine the use of docosahexaenoic acid (DHA) for the treatment of sport-related concussion (SRC) in adolescent athletes. We hypothesize that participants who intake 2 g of DHA daily will not experience differences in recovery compared with participants who take a placebo. This double-blind, randomized controlled pilot trial was performed in a tertiary pediatric sports medicine clinic from 2013 to 2017 in adolescents (14-18 years) presenting with diagnosed SRC within 4 days of injury. Forty participants were randomized into DHA or PLACEBO group and were instructed to take 2 capsules twice daily for 12 weeks. Participants in the DHA group were symptom-free earlier than the PLACEBO group (11.0 vs 16.0 days, P =.08) and were cleared to begin the Return to Sport progression (14.0 vs 19.5 days, P =.12) sooner. The use of 2 g/day of DHA was well-tolerated and did not significantly affect recovery times in adolescent athletes following SRC. Clinical Trial Registration: ClincalTrials.gov, NCT01903525.

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A Pilot Randomized Controlled Trial of Docosahexaenoic Acid for the Treatment of Sport-Related Concussion in Adolescents

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Keywords

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