A phosphine-based redox method for direct conjugation of disulfides

Yong Lu; Lin You; Chuo Chen

doi:10.1039/d2cc04967h

A phosphine-based redox method for direct conjugation of disulfides

Yong Lu, Lin You, Chuo Chen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Technologies for cysteine disulfide detection and conjugation are pivotal to understanding protein functions and developing disulfide-derived therapeutic agents. Currently, disulfide modification requires reductive cleavage prior to functionalization, posing challenges to differentiating disulfides from free thiols. We describe herein Redox-assisted Disulfide Direct Conjugation (RDDC) as a new method to enable disulfide rebridging without cross-reacting with free thiols.

Original language	English (US)
Journal	Chemical Communications
Volume	288
DOIs	https://doi.org/10.1039/d2cc04967h
State	Published - Oct 17 2022

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
General Chemistry
Catalysis

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title = "A phosphine-based redox method for direct conjugation of disulfides",

abstract = "Technologies for cysteine disulfide detection and conjugation are pivotal to understanding protein functions and developing disulfide-derived therapeutic agents. Currently, disulfide modification requires reductive cleavage prior to functionalization, posing challenges to differentiating disulfides from free thiols. We describe herein Redox-assisted Disulfide Direct Conjugation (RDDC) as a new method to enable disulfide rebridging without cross-reacting with free thiols.",

author = "Yong Lu and Lin You and Chuo Chen",

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T1 - A phosphine-based redox method for direct conjugation of disulfides

AU - Lu, Yong

AU - You, Lin

AU - Chen, Chuo

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N2 - Technologies for cysteine disulfide detection and conjugation are pivotal to understanding protein functions and developing disulfide-derived therapeutic agents. Currently, disulfide modification requires reductive cleavage prior to functionalization, posing challenges to differentiating disulfides from free thiols. We describe herein Redox-assisted Disulfide Direct Conjugation (RDDC) as a new method to enable disulfide rebridging without cross-reacting with free thiols.

AB - Technologies for cysteine disulfide detection and conjugation are pivotal to understanding protein functions and developing disulfide-derived therapeutic agents. Currently, disulfide modification requires reductive cleavage prior to functionalization, posing challenges to differentiating disulfides from free thiols. We describe herein Redox-assisted Disulfide Direct Conjugation (RDDC) as a new method to enable disulfide rebridging without cross-reacting with free thiols.

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DO - 10.1039/d2cc04967h

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SN - 1359-7345

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JO - Chemical Communications

JF - Chemical Communications

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A phosphine-based redox method for direct conjugation of disulfides

Abstract

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