A particular GAP in mind

Type 1 neurofibromatosis is a syndrome caused by mutation of the gene NF1, which encodes neurofibromin - a tumor suppressor related to the Ras GAP signaling proteins. A new study of mice that lack a splice variant of neurofibromin discloses learning impairments similar to those of people with neurofibromatosis, and raises questions about the signaling pathways implicating neurofibromin isoforms during synaptic plasticity.