A pain severity-hypothalamic-pituitary-adrenocortical axis interaction: The effects on pain pathways

John P. Garofalo; Richard C. Robinson; Robert J. Gatchel; Zhongyun Wang

doi:10.1111/j.1751-9861.2007.00012.x

A pain severity-hypothalamic-pituitary-adrenocortical axis interaction: The effects on pain pathways

John P. Garofalo, Richard C. Robinson, Robert J. Gatchel, Zhongyun Wang

Physical Medicine & Rehabilitation

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Recent efforts have identified psychosocial and biological factors influencing the pathogenesis of chronic pain. The present study attempted to identify whether these two variables interact and, in turn, represent an underlying mechanism in the transition from acute to chronic pain. Salivary cortisol samples were collected upon waking up and 20 minutes later daily for 2 weeks from acute pain patients. Analyses revealed a direct relationship between pain severity and hypothalamic-pituitary-adrenocortical activity for temporomandibular disorder, and a negative relationship between these variables for low back pain populations. These results highlight the possible interaction between neuroendocrine and psychological factors to increase the risk for chronic pain.

Original language	English (US)
Pages (from-to)	35-42
Number of pages	8
Journal	Journal of Applied Biobehavioral Research
Volume	12
Issue number	1
DOIs	https://doi.org/10.1111/j.1751-9861.2007.00012.x
State	Published - Jan 2007

ASJC Scopus subject areas

Cultural Studies
Experimental and Cognitive Psychology
Clinical Psychology
Social Sciences (miscellaneous)

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A pain severity-hypothalamic-pituitary-adrenocortical axis interaction: The effects on pain pathways

Abstract

ASJC Scopus subject areas

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