Abstract
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor C1q and to a hibernation- specific protein isolated from the plasma of Siberian chipmunks; it forms large homo-oligomers that undergo a series of post-translational modifications. Like adipsin, secretion of Acrp30 is enhanced by insulin, and Acrp30 is an abundant serum protein. Acrp30 may be a factor that participates in the delicately balanced system of energy homeostasis involving food intake and carbohydrate and lipid catabolism. Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes.
Original language | English (US) |
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Pages (from-to) | 26746-26749 |
Number of pages | 4 |
Journal | Journal of Biological Chemistry |
Volume | 270 |
Issue number | 45 |
DOIs | |
State | Published - Nov 10 1995 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology