A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia

Oihane Garcia-Irigoyen; Antonio Moschetta

doi:10.1016/j.cmet.2017.03.014

A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia

Oihane Garcia-Irigoyen, Antonio Moschetta

Pharmacology

Research output: Contribution to journal › Short survey › peer-review

19 Scopus citations

Abstract

During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.

Original language	English (US)
Pages (from-to)	763-764
Number of pages	2
Journal	Cell Metabolism
Volume	25
Issue number	4
DOIs	https://doi.org/10.1016/j.cmet.2017.03.014
State	Published - Apr 4 2017

Keywords

FXR
bile acids
cholestasis
inflammasome
nuclear receptors
sepsis

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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10.1016/j.cmet.2017.03.014

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title = "A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia",

abstract = "During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.",

keywords = "FXR, bile acids, cholestasis, inflammasome, nuclear receptors, sepsis",

author = "Oihane Garcia-Irigoyen and Antonio Moschetta",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Inc.",

year = "2017",

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doi = "10.1016/j.cmet.2017.03.014",

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T1 - A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia

AU - Garcia-Irigoyen, Oihane

AU - Moschetta, Antonio

PY - 2017/4/4

Y1 - 2017/4/4

N2 - During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.

AB - During conditions of impaired bile flow (cholestasis), increased serum bile acids (BAs) are prognostic markers of sepsis. In this issue, Hao et al. (2017) show that the BA receptor FXR binds NLRP3 inflammasome in macrophages and inhibits activation of inflammasome components, thus reducing endotoxemia in cholestasis.

KW - FXR

KW - bile acids

KW - cholestasis

KW - inflammasome

KW - nuclear receptors

KW - sepsis

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DO - 10.1016/j.cmet.2017.03.014

M3 - Short survey

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JO - Cell Metabolism

JF - Cell Metabolism

IS - 4

ER -

A Novel Protective Role for FXR against Inflammasome Activation and Endotoxemia

Abstract

Keywords

ASJC Scopus subject areas

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