A novel family of biodegradable poly(ester amide) elastomers

Hao Cheng; Paulina S. Hill; Daniel J. Siegwart; Nathaniel Vacanti; Abigail K R Lytton-Jean; Seung Woo Cho; Anne Ye; Robert Langer; Daniel G. Anderson

doi:10.1002/adma.201003482

A novel family of biodegradable poly(ester amide) elastomers

Hao Cheng, Paulina S. Hill, Daniel J. Siegwart, Nathaniel Vacanti, Abigail K R Lytton-Jean, Seung Woo Cho, Anne Ye, Robert Langer, Daniel G. Anderson

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Biodegradable elastomeric materials have particular utility in tissue engineering applications because their compliance under force closely resembles the elastic nature of many human tissues. A family of biodegradable poly(ester amide) elastomers were developed, with excellent elasticity under hydrated conditions, good in vivo biocompatibility and a slow degradation rate. This study sheds light on the structure-property relationship behind designing biodegradable elastomeric materials.

Original language	English (US)
Pages (from-to)	H95-H100
Journal	Advanced Materials
Volume	23
Issue number	12
DOIs	https://doi.org/10.1002/adma.201003482
State	Published - Mar 25 2011

Keywords

nerve regeneration
regenerative medicine
scaffolds
tissue engineering
young's modulus

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201003482

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AU - Lytton-Jean, Abigail K R

AU - Cho, Seung Woo

AU - Ye, Anne

AU - Langer, Robert

AU - Anderson, Daniel G.

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AB - Biodegradable elastomeric materials have particular utility in tissue engineering applications because their compliance under force closely resembles the elastic nature of many human tissues. A family of biodegradable poly(ester amide) elastomers were developed, with excellent elasticity under hydrated conditions, good in vivo biocompatibility and a slow degradation rate. This study sheds light on the structure-property relationship behind designing biodegradable elastomeric materials.

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KW - regenerative medicine

KW - scaffolds

KW - tissue engineering

KW - young's modulus

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A novel family of biodegradable poly(ester amide) elastomers

Abstract

Keywords

ASJC Scopus subject areas

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