Abstract
Inflammatory myofibroblastic tumors (IMTs) are uncommon lesions primarily affecting children and young adults. They have rarely been described in infants, with a very small number described in neonates. Structural rearrangements in the anaplastic large-cell lymphoma kinase gene (ALK) has contributed to our categorizing this lesion as a neoplasm. In addition, rearrangements of the ALK gene have been implicated in the pathogenicity of many other hematolymphoid and nonhematolymphoid tumors, typically involving 2p23 with different partners or with pericentric inversion. We report a previously undescribed cryptic deletion and intrachromosomal-insertional translocation of the 3'-region of the ALK gene from 2p23 to the 2q33-q35 in an IMT of a newborn patient with an apparently normal G-band karyotype of the tumor.
Original language | English (US) |
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Pages (from-to) | 353-356 |
Number of pages | 4 |
Journal | Cancer Genetics |
Volume | 206 |
Issue number | 9-10 |
DOIs | |
State | Published - Sep 1 2013 |
Keywords
- ALK
- EXIT procedure
- Inflammatory myofibroblastic tumor
- Neonate
- Prenatal diagnosis
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research