A novel ALK rearrangement in an inflammatory myofibroblastic tumor in a neonate

Nicci Owusu-Brackett; Romaine Johnson; David T. Schindel; Prasad Koduru; Sandy Cope-Yokoyama

doi:10.1016/j.cancergen.2013.10.002

A novel ALK rearrangement in an inflammatory myofibroblastic tumor in a neonate

Nicci Owusu-Brackett, Romaine Johnson, David T. Schindel, Prasad Koduru, Sandy Cope-Yokoyama

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Inflammatory myofibroblastic tumors (IMTs) are uncommon lesions primarily affecting children and young adults. They have rarely been described in infants, with a very small number described in neonates. Structural rearrangements in the anaplastic large-cell lymphoma kinase gene (ALK) has contributed to our categorizing this lesion as a neoplasm. In addition, rearrangements of the ALK gene have been implicated in the pathogenicity of many other hematolymphoid and nonhematolymphoid tumors, typically involving 2p23 with different partners or with pericentric inversion. We report a previously undescribed cryptic deletion and intrachromosomal-insertional translocation of the 3'-region of the ALK gene from 2p23 to the 2q33-q35 in an IMT of a newborn patient with an apparently normal G-band karyotype of the tumor.

Original language	English (US)
Pages (from-to)	353-356
Number of pages	4
Journal	Cancer Genetics
Volume	206
Issue number	9-10
DOIs	https://doi.org/10.1016/j.cancergen.2013.10.002
State	Published - Sep 1 2013

Keywords

ALK
EXIT procedure
Inflammatory myofibroblastic tumor
Neonate
Prenatal diagnosis

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/j.cancergen.2013.10.002

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title = "A novel ALK rearrangement in an inflammatory myofibroblastic tumor in a neonate",

abstract = "Inflammatory myofibroblastic tumors (IMTs) are uncommon lesions primarily affecting children and young adults. They have rarely been described in infants, with a very small number described in neonates. Structural rearrangements in the anaplastic large-cell lymphoma kinase gene (ALK) has contributed to our categorizing this lesion as a neoplasm. In addition, rearrangements of the ALK gene have been implicated in the pathogenicity of many other hematolymphoid and nonhematolymphoid tumors, typically involving 2p23 with different partners or with pericentric inversion. We report a previously undescribed cryptic deletion and intrachromosomal-insertional translocation of the 3'-region of the ALK gene from 2p23 to the 2q33-q35 in an IMT of a newborn patient with an apparently normal G-band karyotype of the tumor.",

keywords = "ALK, EXIT procedure, Inflammatory myofibroblastic tumor, Neonate, Prenatal diagnosis",

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AU - Owusu-Brackett, Nicci

AU - Johnson, Romaine

AU - Schindel, David T.

AU - Koduru, Prasad

AU - Cope-Yokoyama, Sandy

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Inflammatory myofibroblastic tumors (IMTs) are uncommon lesions primarily affecting children and young adults. They have rarely been described in infants, with a very small number described in neonates. Structural rearrangements in the anaplastic large-cell lymphoma kinase gene (ALK) has contributed to our categorizing this lesion as a neoplasm. In addition, rearrangements of the ALK gene have been implicated in the pathogenicity of many other hematolymphoid and nonhematolymphoid tumors, typically involving 2p23 with different partners or with pericentric inversion. We report a previously undescribed cryptic deletion and intrachromosomal-insertional translocation of the 3'-region of the ALK gene from 2p23 to the 2q33-q35 in an IMT of a newborn patient with an apparently normal G-band karyotype of the tumor.

AB - Inflammatory myofibroblastic tumors (IMTs) are uncommon lesions primarily affecting children and young adults. They have rarely been described in infants, with a very small number described in neonates. Structural rearrangements in the anaplastic large-cell lymphoma kinase gene (ALK) has contributed to our categorizing this lesion as a neoplasm. In addition, rearrangements of the ALK gene have been implicated in the pathogenicity of many other hematolymphoid and nonhematolymphoid tumors, typically involving 2p23 with different partners or with pericentric inversion. We report a previously undescribed cryptic deletion and intrachromosomal-insertional translocation of the 3'-region of the ALK gene from 2p23 to the 2q33-q35 in an IMT of a newborn patient with an apparently normal G-band karyotype of the tumor.

KW - ALK

KW - EXIT procedure

KW - Inflammatory myofibroblastic tumor

KW - Neonate

KW - Prenatal diagnosis

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ER -

A novel ALK rearrangement in an inflammatory myofibroblastic tumor in a neonate

Abstract

Keywords

ASJC Scopus subject areas

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