A new MHC locus that influences class I peptide presentation

William A. Simmons, Derry C. Roopenian, Scott G. Summerfield, Richard C. Jones, Begona Galocha, Gregory J. Christianson, Shanna D. Maika, Ming Zhou, Simon J. Gaskell, Robert S. Bordoli, Hidde L. Ploegh, Clive A. Slaughter, Kirsten Fischer Lindahl, Robert E Hammer, Joel D Taurog

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We have investigated the HLA-B27-restricted CTL response to HY minor histocompatibility antigens in rats and mice transgenic for HLA-B27 and human β2-microglobulin. A polymorphism was found at a locus within the H2 complex, producing two distinct but overlapping sets of B27-presented HY peptides. The locus, named Cim2, mapped between the K and Pb loci, and its product is therefore distinct from TAP, LMP, and tapasin. Identical findings in rats and mice, including identical HY peptide sequences and the failure of a rat Tap2A transgene to alter CTL recognition, suggest that a homologous locus with similar polymorphism exists in the rat. Cim2, or a closely linked locus, was found to exert a broad effect on peptide loading of both HLA-B27 and mouse class I alleles. The data thus establish a strong, previously unrecognized MHC-encoded influence on the class I antigen pathway.

Original languageEnglish (US)
Pages (from-to)641-651
Number of pages11
Issue number5
StatePublished - Nov 1997

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases


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