TY - JOUR
T1 - A new MHC locus that influences class I peptide presentation
AU - Simmons, William A.
AU - Roopenian, Derry C.
AU - Summerfield, Scott G.
AU - Jones, Richard C.
AU - Galocha, Begona
AU - Christianson, Gregory J.
AU - Maika, Shanna D.
AU - Zhou, Ming
AU - Gaskell, Simon J.
AU - Bordoli, Robert S.
AU - Ploegh, Hidde L.
AU - Slaughter, Clive A.
AU - Lindahl, Kirsten Fischer
AU - Hammer, Robert E
AU - Taurog, Joel D
N1 - Funding Information:
The technical assistance of Nimman Satumtira, Martha Dorris, and Graham Fox, and the secretarial assistance of Sherry Fariss are gratefully acknowledged. We also thank Drs. Geoffrey Butcher and James Forman for reagents and helpful discussions, Dr. Tim Townes for animals, and Drs. Jerold Woodward and Patrick Stuart for initiating the backcrossing of the 56-3 transgene locus onto BALB/c and B6 backgrounds. This work was supported by NIH R01 grants DK47692 and AR38319 (J. D. T.) and AI28802 (D. C. R.). W. A. S. was supported during part of this work by NIH Training Grant CA09082-20. The locus name MHC class I modifier-2 ( Cim2 ) has been approved by The International Committee on Standardized Genetic Nomenclature for Mice.
PY - 1997/11
Y1 - 1997/11
N2 - We have investigated the HLA-B27-restricted CTL response to HY minor histocompatibility antigens in rats and mice transgenic for HLA-B27 and human β2-microglobulin. A polymorphism was found at a locus within the H2 complex, producing two distinct but overlapping sets of B27-presented HY peptides. The locus, named Cim2, mapped between the K and Pb loci, and its product is therefore distinct from TAP, LMP, and tapasin. Identical findings in rats and mice, including identical HY peptide sequences and the failure of a rat Tap2A transgene to alter CTL recognition, suggest that a homologous locus with similar polymorphism exists in the rat. Cim2, or a closely linked locus, was found to exert a broad effect on peptide loading of both HLA-B27 and mouse class I alleles. The data thus establish a strong, previously unrecognized MHC-encoded influence on the class I antigen pathway.
AB - We have investigated the HLA-B27-restricted CTL response to HY minor histocompatibility antigens in rats and mice transgenic for HLA-B27 and human β2-microglobulin. A polymorphism was found at a locus within the H2 complex, producing two distinct but overlapping sets of B27-presented HY peptides. The locus, named Cim2, mapped between the K and Pb loci, and its product is therefore distinct from TAP, LMP, and tapasin. Identical findings in rats and mice, including identical HY peptide sequences and the failure of a rat Tap2A transgene to alter CTL recognition, suggest that a homologous locus with similar polymorphism exists in the rat. Cim2, or a closely linked locus, was found to exert a broad effect on peptide loading of both HLA-B27 and mouse class I alleles. The data thus establish a strong, previously unrecognized MHC-encoded influence on the class I antigen pathway.
UR - http://www.scopus.com/inward/record.url?scp=0031462712&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031462712&partnerID=8YFLogxK
U2 - 10.1016/S1074-7613(00)80385-4
DO - 10.1016/S1074-7613(00)80385-4
M3 - Article
C2 - 9390688
AN - SCOPUS:0031462712
SN - 1074-7613
VL - 7
SP - 641
EP - 651
JO - Immunity
JF - Immunity
IS - 5
ER -