The centromeric cohesin protector Shugoshin (Sgo) and the spindle checkpoint protein Mad2 are known to act in distinct pathways for ensuring accurate chromosome segregation during eukaryotic cell division. In this issue of The EMBO Journal, Orth et al (2011) describe an unexpected physical interaction between vertebrate Sgo and Mad2, as well as indications of their potential mutual regulation in meiosis.
ASJC Scopus subject areas
- General Neuroscience
- Molecular Biology
- General Biochemistry, Genetics and Molecular Biology
- General Immunology and Microbiology