A “KU” new sensor for cytosolic DNA in T cells

Jianjun Wu; Nan Yan

doi:10.1016/j.immuni.2021.03.017

A “KU” new sensor for cytosolic DNA in T cells

Jianjun Wu, Nan Yan

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Adaptive immune cells are usually not equipped with pattern recognition receptors. In this issue of Immunity, Wang et al. revealed an “innate-like” cytosolic DNA-sensing mechanism by the KU complex in aged CD4⁺ T cells, which exacerbates aging-related autoimmunity.

Original language	English (US)
Pages (from-to)	603-605
Number of pages	3
Journal	Immunity
Volume	54
Issue number	4
DOIs	https://doi.org/10.1016/j.immuni.2021.03.017
State	Published - Apr 13 2021

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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10.1016/j.immuni.2021.03.017

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title = "A “KU” new sensor for cytosolic DNA in T cells",

abstract = "Adaptive immune cells are usually not equipped with pattern recognition receptors. In this issue of Immunity, Wang et al. revealed an “innate-like” cytosolic DNA-sensing mechanism by the KU complex in aged CD4+ T cells, which exacerbates aging-related autoimmunity.",

author = "Jianjun Wu and Nan Yan",

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AB - Adaptive immune cells are usually not equipped with pattern recognition receptors. In this issue of Immunity, Wang et al. revealed an “innate-like” cytosolic DNA-sensing mechanism by the KU complex in aged CD4+ T cells, which exacerbates aging-related autoimmunity.

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A “KU” new sensor for cytosolic DNA in T cells

Abstract

ASJC Scopus subject areas

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