A Hyperkinetic Redox Sensor Drives Flies to Sleep

Pin Xu; Kimberly H. Cox; Joseph S. Takahashi

doi:10.1016/j.tins.2019.05.007

A Hyperkinetic Redox Sensor Drives Flies to Sleep

Pin Xu, Kimberly H. Cox, Joseph S. Takahashi

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

Original language	English (US)
Pages (from-to)	514-517
Number of pages	4
Journal	Trends in Neurosciences
Volume	42
Issue number	8
DOIs	https://doi.org/10.1016/j.tins.2019.05.007
State	Published - Aug 2019

Keywords

Drosophila
NADPH
redox state
sleep switch

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.tins.2019.05.007

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title = "A Hyperkinetic Redox Sensor Drives Flies to Sleep",

abstract = "Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.",

keywords = "Drosophila, NADPH, redox state, sleep switch",

author = "Pin Xu and Cox, {Kimberly H.} and Takahashi, {Joseph S.}",

note = "Funding Information: J.S.T. is supported by the National Institutes of Health ( R01 AG045795 and R01 NS106657 ) and is an Investigator in the Howard Hughes Medical Institute. Publisher Copyright: {\textcopyright} 2019",

year = "2019",

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AU - Xu, Pin

AU - Cox, Kimberly H.

AU - Takahashi, Joseph S.

N1 - Funding Information: J.S.T. is supported by the National Institutes of Health ( R01 AG045795 and R01 NS106657 ) and is an Investigator in the Howard Hughes Medical Institute. Publisher Copyright: © 2019

PY - 2019/8

Y1 - 2019/8

N2 - Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

AB - Several different potassium channels modulate the activity of sleep-promoting neurons in the Drosophila brain, but the regulation of these channels is not completely understood. A recent study (Kempf et al., Nature, 2019) found that one of the potassium channel subunits, Hyperkinetic, alters the firing properties of sleep-promoting neurons in response to NADPH oxidation. These findings are the first to link cellular redox state and mitochondrial metabolism directly to sleep.

KW - Drosophila

KW - NADPH

KW - redox state

KW - sleep switch

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ER -

A Hyperkinetic Redox Sensor Drives Flies to Sleep

Abstract

Keywords

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