A History of Bone Marrow Transplantation

M. Teresa de la Morena; Richard A. Gatti

doi:10.1016/j.iac.2009.11.005

A History of Bone Marrow Transplantation

M. Teresa de la Morena, Richard A. Gatti

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.

Original language	English (US)
Pages (from-to)	1-15
Number of pages	15
Journal	Immunology and Allergy Clinics of North America
Volume	30
Issue number	1
DOIs	https://doi.org/10.1016/j.iac.2009.11.005
State	Published - Feb 2010

Keywords

Bone marrow transplantation
History
Primary immunodeficiency diseases

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/j.iac.2009.11.005

Cite this

@article{f9407f8265e241f2a251a48afc063d99,

title = "A History of Bone Marrow Transplantation",

abstract = "The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.",

keywords = "Bone marrow transplantation, History, Primary immunodeficiency diseases",

author = "{de la Morena}, {M. Teresa} and Gatti, {Richard A.}",

year = "2010",

month = feb,

doi = "10.1016/j.iac.2009.11.005",

language = "English (US)",

volume = "30",

pages = "1--15",

journal = "Immunology and Allergy Clinics of North America",

issn = "0889-8561",

publisher = "W.B. Saunders Ltd",

number = "1",

}

TY - JOUR

T1 - A History of Bone Marrow Transplantation

AU - de la Morena, M. Teresa

AU - Gatti, Richard A.

PY - 2010/2

Y1 - 2010/2

N2 - The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.

AB - The last 40 years has seen the emergence of hematopoietic stem cell transplantation as a therapeutic modality for fatal diseases and as a curative option for individuals born with inherited disorders that carry limited life expectancy and poor quality of life. Despite the rarity of many primary immunodeficiency diseases, these disorders have led the way toward innovative therapies and further provide insights into mechanisms of immunologic reconstitution applicable to all hematopoietic stem cell transplants. This article represents a historical perspective of the early investigators and their contributions. It also reviews the parallel work that oncologists and immunologists have undertaken to treat both primary immunodeficiencies and hematologic malignancies.

KW - Bone marrow transplantation

KW - History

KW - Primary immunodeficiency diseases

UR - http://www.scopus.com/inward/record.url?scp=74749086546&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=74749086546&partnerID=8YFLogxK

U2 - 10.1016/j.iac.2009.11.005

DO - 10.1016/j.iac.2009.11.005

M3 - Review article

C2 - 20113883

AN - SCOPUS:74749086546

SN - 0889-8561

VL - 30

SP - 1

EP - 15

JO - Immunology and Allergy Clinics of North America

JF - Immunology and Allergy Clinics of North America

IS - 1

ER -

A History of Bone Marrow Transplantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this