A concise synthesis of (+)-SCH 351448

Omid Soltani, Jef K. De Brabander

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


(Chemical Equation Presented) We describe a highly convergent synthetic approach to the natural product (+)-SCH 351448 (1) - a hexane-soluble heptacoordinate monosodium salt of a C2-symmetrical macrocyclic dilactone. Our approach implements a photochemical acylation as the key step to combine two nearly identical but orthogonal C1-C29 fragments, followed by a base-induced intramolecular acylation and deprotection to yield the natural product.

Original languageEnglish (US)
Pages (from-to)2791-2793
Number of pages3
JournalOrganic Letters
Issue number13
StatePublished - 2005

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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