A comparison of three antibiotic regimens for eradication of Haemophilus influenzae type b from the pharynx of infants and children

The purpose of this brief communication is to report results with three antimicrobial agents that were given in an attempt to eliminate pharyngeal carriage of H influenzae type b infants and children. Two groups of subjects were studied. Group 1 consisted of infants and children who were close contacts of patients with culture-proved disease treated at Parkland Memorial Hospital or Children's Medical Center, Dallas. Group 2 consisted of 362 infants and children who were part of a large 'mother's day out' program in which four cases of H influenzae type b disease occurred in a ten-day period.