A CLOCK polymorphism associated with human diurnal preference

Daniel Katzenberg, Terry Young, Laurel Finn, Ling Lin, David P. King, Joseph S. Takahashi, Emmanuel Mignot

Research output: Contribution to journalArticlepeer-review

213 Scopus citations


A single nucleotide polymorphism located in the 3' flanking region of the human CLOCK gene was investigated as a predictor of diurnal preference in a population-based random sample of 410 normal adults. Morningness- eveningness preferences were determined using the 19-item Home-Ostberg questionnaire. Subjects carrying one of the two CLOCK alleles, 3111C, had a significantly lower mean Horne-Ostberg score. The distribution of scores was clearly shifted toward eveningness for these subjects. The score difference was independent of age, sex and ethnic heritage, thus making population stratification effects unlikely to explain this difference. These subjects had a substantial 10- to 44-minute delay in preferred timing for activity or sleep episodes. We suggest that the identified polymorphism or another tightly linked polymorphism within the CLOCK gene or its regulatory elements may be responsible for the finding.

Original languageEnglish (US)
Pages (from-to)569-576
Number of pages8
Issue number6
StatePublished - Sep 15 1998


  • Circadian
  • Horne-Ostberg
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Clinical Neurology
  • Physiology (medical)


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