A cholesterol-sensing mechanism unfolds

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Squalene monooxygenase (SM), which synthesizes a cholesterol precursor, is degraded when cholesterol levels in the endoplasmic reticulum (ER) membrane are high, but the signal for degradation was not known. In this issue of JBC, Brown and co-workers identify an N-terminal domain in SM that intercon-verts in a cholesterol-sensitive manner between a membrane-binding amphipathic helix and a soluble degradation-prone segment, providing the first example of a cholesterol-degron collaboration.

Original languageEnglish (US)
Pages (from-to)19974-19975
Number of pages2
JournalJournal of Biological Chemistry
Issue number49
StatePublished - Dec 8 2017
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'A cholesterol-sensing mechanism unfolds'. Together they form a unique fingerprint.

Cite this