Abstract
Metaplastic breast cancer is a rare and often chemo-refractory subtype of breast cancer with poor prognosis and limited treatment options. Recent studies have reported overexpression of programmed death ligand 1 (PD-L1) in metaplastic breast cancers, and there are several reports of anti-PD-1/L1 being potentially active in this disease. In this case series, we present 5 patients with metastatic metaplastic breast cancer treated with anti-PD-1-based therapy at a single center, with 3 of 5 cases demonstrating a response to therapy, and one of the responding cases being a metaplastic lobular carcinoma with low-level hormone receptor expression. Cases were evaluated for PD-L1 expression, tumor infiltrating lymphocytes (TILs), DNA mutations, RNA sequencing, and T-cell receptor sequencing. Duration of the response in these cases was limited, in contrast to the more durable responses noted in other recently published reports.
Original language | English (US) |
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Article number | 635237 |
Journal | Frontiers in Oncology |
Volume | 11 |
DOIs | |
State | Published - Jun 8 2021 |
Externally published | Yes |
Keywords
- PD-L1
- PI3K
- TNBC
- immunotherapy
- metaplastic breast cancer
ASJC Scopus subject areas
- Oncology
- Cancer Research