A biological model of aphasia rehabilitation: Pharmacological perspectives

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Background: Aphasia is a multi-modality disturbance of speech, language, and memory caused by neurological injury, particularly stroke. Aims: This review article views aphasia as fundamentally a disease of the brain, and aims to survey biological treatments for aphasia that address amelioration of brain injury. Main Contribution: The review examines the effects of different drugs on both direct and indirect mechanisms of neural circuit reorganisation, gauged through effects on multi-modal measures of speech, language, and memory. Based on this review, therapists might choose to analyse and change the pharmacological state of their patients with aphasia. Conclusions: We conclude that (a) both biological and behavioural therapies affect brain repair and reorganisation; (b) pharmacotherapy is not yet proven, but has promise, but only when accompanied by concomitant behavioural therapy; (c) the most important biological interventions that can be accomplished at present are to withdraw certain drugs that impede aphasia recovery and to administer anti-depressants to all patients with major or minor poststroke depression.

Original languageEnglish (US)
Pages (from-to)473-492
Number of pages20
Issue number5-7
StatePublished - May 2004
Externally publishedYes

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Language and Linguistics
  • Developmental and Educational Psychology
  • Linguistics and Language
  • Neurology
  • Clinical Neurology
  • LPN and LVN


Dive into the research topics of 'A biological model of aphasia rehabilitation: Pharmacological perspectives'. Together they form a unique fingerprint.

Cite this