Abstract
To determine the role of central serotonin 5-HT3 receptors in respiratory motor control, respiratory motor bursts were recorded from hypoglossal (XII) nerve rootlets on isolated adult turtle brainstems during bath-application of 5-HT3 receptor agonists and antagonists. mCPBG and PBG (5-HT3 receptor agonists) acutely increased XII burst frequency and regularity, and decreased bursts/episode. Tropisetron and MDL72222 (5-HT3 antagonists) increased bursts/episode, suggesting endogenous 5-HT3 receptor activation modulates burst timing in vitro. Tropisetron blocked all mCPBG effects, and the PBG-induced reduction in bursts/episode. Tropisetron application following mCPBG application did not reverse the long-lasting (2 h) mCPBG-induced decrease in bursts/episode. We conclude that endogenous 5-HT3 receptor activation regulates respiratory frequency, regularity, and episodicity in turtles and may induce a form of respiratory plasticity with the long-lasting changes in respiratory regularity.
Original language | English (US) |
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Pages (from-to) | 42-52 |
Number of pages | 11 |
Journal | Respiratory Physiology and Neurobiology |
Volume | 172 |
Issue number | 1-2 |
DOIs | |
State | Published - Jun 30 2010 |
Keywords
- 5-HT receptors
- Chelonian
- Episodic breathing
- Frequency
- Plasticity
- Regularity
- Reptile
- Respiratory motor control
- Serotonin
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology
- Pulmonary and Respiratory Medicine