Abstract
A phase II trial of 5-fluorouracil (5-FU) [250450 mg/m2/day × 5 days as an intravenous (IV) bolus] combined with calcium leucovorin (500 mg/m2/day × 5 1/2 days by continuous IV infusion) administered on a 28-day schedule was performed in 15 patients with advanced hepatocellular carcinoma. The median age was 58 years; performance status ranged from 50 to 100% Of 15 evaluable patients, 1 (7% had a partial response lasting 2.4 months; 8 (53% had stable disease with a median duration of 5.7 months; and 6 (40% had progressive disease with a median time to progression of 2.7 months. Median survival was 3.8 months. Treatment with 5-FU and calcium leucovorin was moderately well tolerated; 9% of the treatment courses were complicated by grade 3 or 4 hematological toxicity, and 10% of the courses were complicated by grade 3 or 4 gastrointestinal toxicity. Despite the efficacy of the combination of 5-FU and leucovorin in advanced colorectal cancer, our results document the general resistance of hepatocellular carcinoma to modulated 5-FU.
Original language | English (US) |
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Pages (from-to) | 460-463 |
Number of pages | 4 |
Journal | Cancer Investigation |
Volume | 13 |
Issue number | 5 |
DOIs | |
State | Published - 1995 |
ASJC Scopus subject areas
- Oncology
- Cancer Research