(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga

Miriam H. Kossuga; John B. MacMillan; Evan W. Rogers; Tadeusz F. Molinski; Gislene G F Nascimento; Rosana M. Rocha; Roberto G S Berlinck

doi:10.1021/np049782q

(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga

Miriam H. Kossuga, John B. MacMillan, Evan W. Rogers, Tadeusz F. Molinski, Gislene G F Nascimento, Rosana M. Rocha, Roberto G S Berlinck

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 μg/ mL and against Candida glabrata with a MIC of 30 μg/mL.

Original language	English (US)
Pages (from-to)	1879-1881
Number of pages	3
Journal	Journal of Natural Products
Volume	67
Issue number	11
DOIs	https://doi.org/10.1021/np049782q
State	Published - Nov 2004

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga",

abstract = "A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 μg/ mL and against Candida glabrata with a MIC of 30 μg/mL.",

author = "Kossuga, {Miriam H.} and MacMillan, {John B.} and Rogers, {Evan W.} and Molinski, {Tadeusz F.} and Nascimento, {Gislene G F} and Rocha, {Rosana M.} and Berlinck, {Roberto G S}",

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AU - Kossuga, Miriam H.

AU - MacMillan, John B.

AU - Rogers, Evan W.

AU - Molinski, Tadeusz F.

AU - Nascimento, Gislene G F

AU - Rocha, Rosana M.

AU - Berlinck, Roberto G S

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AB - A new antifungal agent, (2S,3R)-2-aminododecan-3-ol (1), has been isolated from the ascidian Clavelina oblonga collected in Brazil. The structure of 1 was established by analysis of spectroscopic data, including absolute stereochemistry determined by circular dichroism analysis of the dibenzoyl derivative 2. Compound 1 displayed antifungal activity against Candida albicans ATCC 10231 with a MIC of 0.7 μg/ mL and against Candida glabrata with a MIC of 30 μg/mL.

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(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga

Abstract

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