2-Cyanopyridazin-3(2H)-ones: Effective and chemoselective electrophilic cyanating agents

Jeum Jong Kim; Deok Heon Kweon; Su Dong Cho; Ho Kyun Kim; Eun Young Jung; Sang Gyeong Lee; J R Falck; Yong Jin Yoon

doi:10.1016/j.tet.2005.03.138

2-Cyanopyridazin-3(2H)-ones: Effective and chemoselective electrophilic cyanating agents

Jeum Jong Kim, Deok Heon Kweon, Su Dong Cho, Ho Kyun Kim, Eun Young Jung, Sang Gyeong Lee, J R Falck, Yong Jin Yoon

Biochemistry

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

2-Cyanopyridazin-3(2H)-ones are novel, effective, selective and electrophilic cyanating agents. A variety of amino, thiol and carbon nucleophiles are chemoselectively N-, S- or C-cyanated in excellent yield using 2-cyanopyridanzin-3(2H)-ones in water or tetrahydrofuran.

Original language	English (US)
Pages (from-to)	5889-5894
Number of pages	6
Journal	Tetrahedron
Volume	61
Issue number	24
DOIs	https://doi.org/10.1016/j.tet.2005.03.138
State	Published - Jun 13 2005

Keywords

2-Cyanopyridazin-3(2H)- ones
Electrophilic cyanating agent
N-, S- or C-cyanation

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/j.tet.2005.03.138

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title = "2-Cyanopyridazin-3(2H)-ones: Effective and chemoselective electrophilic cyanating agents",

abstract = "2-Cyanopyridazin-3(2H)-ones are novel, effective, selective and electrophilic cyanating agents. A variety of amino, thiol and carbon nucleophiles are chemoselectively N-, S- or C-cyanated in excellent yield using 2-cyanopyridanzin-3(2H)-ones in water or tetrahydrofuran.",

keywords = "2-Cyanopyridazin-3(2H)- ones, Electrophilic cyanating agent, N-, S- or C-cyanation",

author = "Kim, {Jeum Jong} and Kweon, {Deok Heon} and Cho, {Su Dong} and Kim, {Ho Kyun} and Jung, {Eun Young} and Lee, {Sang Gyeong} and Falck, {J R} and Yoon, {Yong Jin}",

note = "Funding Information: This work was supported by a grant from the Korea Science and Engineering Foundation (KOSEF) to the Environmental Biotechnology National Core Research Center (grant #: R15-2003-012-02001-0).",

year = "2005",

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day = "13",

doi = "10.1016/j.tet.2005.03.138",

language = "English (US)",

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pages = "5889--5894",

journal = "Tetrahedron",

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number = "24",

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T1 - 2-Cyanopyridazin-3(2H)-ones

T2 - Effective and chemoselective electrophilic cyanating agents

AU - Kim, Jeum Jong

AU - Kweon, Deok Heon

AU - Cho, Su Dong

AU - Kim, Ho Kyun

AU - Jung, Eun Young

AU - Lee, Sang Gyeong

AU - Falck, J R

AU - Yoon, Yong Jin

N1 - Funding Information: This work was supported by a grant from the Korea Science and Engineering Foundation (KOSEF) to the Environmental Biotechnology National Core Research Center (grant #: R15-2003-012-02001-0).

PY - 2005/6/13

Y1 - 2005/6/13

N2 - 2-Cyanopyridazin-3(2H)-ones are novel, effective, selective and electrophilic cyanating agents. A variety of amino, thiol and carbon nucleophiles are chemoselectively N-, S- or C-cyanated in excellent yield using 2-cyanopyridanzin-3(2H)-ones in water or tetrahydrofuran.

AB - 2-Cyanopyridazin-3(2H)-ones are novel, effective, selective and electrophilic cyanating agents. A variety of amino, thiol and carbon nucleophiles are chemoselectively N-, S- or C-cyanated in excellent yield using 2-cyanopyridanzin-3(2H)-ones in water or tetrahydrofuran.

KW - 2-Cyanopyridazin-3(2H)- ones

KW - Electrophilic cyanating agent

KW - N-, S- or C-cyanation

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DO - 10.1016/j.tet.2005.03.138

M3 - Article

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JO - Tetrahedron

JF - Tetrahedron

IS - 24

ER -

2-Cyanopyridazin-3(2H)-ones: Effective and chemoselective electrophilic cyanating agents

Abstract

Keywords

ASJC Scopus subject areas

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