TY - JOUR
T1 - 14,15-cis-episulfide-eicosatrienoic acid, and 'epoxygenase' eicosanoid analog, inhibits ionophore- but not thrombin-induced platelet aggregation
AU - Bernstrom, K.
AU - Malcolm, K.
AU - Mcgee, J.
AU - Maclouf, J.
AU - Levy-Toledano, S.
AU - Falck, J R
AU - Fitzpatrick, F. A.
PY - 1991
Y1 - 1991
N2 - An 'epoxygenase' eicosanoid analog, 14,15-cis-episulfide-eicosatrienoic acid, has several unique pharmacological effects on platelets. These include (i) inhibition of ionophore A23187- but not thrombin-induced activation, (ii) inhibition of thromboxane B2 biosynthesis derived from endogenous but not exogenous arachidonic acid, and (iii) attenuation of ionophore-mediated increases in cytosolic Ca2+ when extracellular or membrane Ca2+ is available but not when these pools are excluded. Neither elevation of cyclic AMP levels, a potent inhibitory process, nor direct antagonism of the prostaglandin H2/thromboxane A2 receptor is responsible for the actions of 14,15-cis-episulfide-eicosatrienoic acid. These properties distinguish 14,15-cis-episulfide-eicosatrienoic acid from other antiaggregatory substances.
AB - An 'epoxygenase' eicosanoid analog, 14,15-cis-episulfide-eicosatrienoic acid, has several unique pharmacological effects on platelets. These include (i) inhibition of ionophore A23187- but not thrombin-induced activation, (ii) inhibition of thromboxane B2 biosynthesis derived from endogenous but not exogenous arachidonic acid, and (iii) attenuation of ionophore-mediated increases in cytosolic Ca2+ when extracellular or membrane Ca2+ is available but not when these pools are excluded. Neither elevation of cyclic AMP levels, a potent inhibitory process, nor direct antagonism of the prostaglandin H2/thromboxane A2 receptor is responsible for the actions of 14,15-cis-episulfide-eicosatrienoic acid. These properties distinguish 14,15-cis-episulfide-eicosatrienoic acid from other antiaggregatory substances.
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M3 - Article
C2 - 1847490
AN - SCOPUS:0026031063
SN - 0026-895X
VL - 39
SP - 114
EP - 119
JO - Molecular Pharmacology
JF - Molecular Pharmacology
IS - 2
ER -