1.38 - Regeneration of Retinal Ganglion Cell Axons

Kevin K. Park

doi:10.1016/B978-0-12-809324-5.23903-5

1.38 - Regeneration of Retinal Ganglion Cell Axons

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Like other projection neurons in the central nervous system, retinal ganglion cells (RGCs) in adult mammals generally do not regenerate their axons after injury. Much effort has been made on elucidating the cellular and molecular mechanisms that underlie the regenerative failure in these neurons. Numerous molecules within RGCs that regulate axon regeneration have now been identified, including various epigenetic factors, transcription factors, growth repressive molecules, signaling proteins and cell adhesion molecules. Furthermore, studies also point to the important roles that interneurons and glial cells in the retina play in regulating RGC axon regeneration.

Original language	English (US)
Title of host publication	The Senses
Subtitle of host publication	A Comprehensive Reference: Volume 1-7, Second Edition
Publisher	Elsevier
Pages	630-641
Number of pages	12
Volume	1
ISBN (Electronic)	9780128054093
ISBN (Print)	9780128054086
DOIs	https://doi.org/10.1016/B978-0-12-809324-5.23903-5
State	Published - Jan 1 2020
Externally published	Yes

Keywords

Axon growth
Axon injury
Axon regeneration
Axon regrowth
Neuronal regeneration
Optic nerve regeneration
PTEN
Retina
Retinal ganglion cells
STAT3
Transcription factors

ASJC Scopus subject areas

General Medicine
General Neuroscience

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10.1016/B978-0-12-809324-5.23903-5

Cite this

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abstract = "Like other projection neurons in the central nervous system, retinal ganglion cells (RGCs) in adult mammals generally do not regenerate their axons after injury. Much effort has been made on elucidating the cellular and molecular mechanisms that underlie the regenerative failure in these neurons. Numerous molecules within RGCs that regulate axon regeneration have now been identified, including various epigenetic factors, transcription factors, growth repressive molecules, signaling proteins and cell adhesion molecules. Furthermore, studies also point to the important roles that interneurons and glial cells in the retina play in regulating RGC axon regeneration.",

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N2 - Like other projection neurons in the central nervous system, retinal ganglion cells (RGCs) in adult mammals generally do not regenerate their axons after injury. Much effort has been made on elucidating the cellular and molecular mechanisms that underlie the regenerative failure in these neurons. Numerous molecules within RGCs that regulate axon regeneration have now been identified, including various epigenetic factors, transcription factors, growth repressive molecules, signaling proteins and cell adhesion molecules. Furthermore, studies also point to the important roles that interneurons and glial cells in the retina play in regulating RGC axon regeneration.

AB - Like other projection neurons in the central nervous system, retinal ganglion cells (RGCs) in adult mammals generally do not regenerate their axons after injury. Much effort has been made on elucidating the cellular and molecular mechanisms that underlie the regenerative failure in these neurons. Numerous molecules within RGCs that regulate axon regeneration have now been identified, including various epigenetic factors, transcription factors, growth repressive molecules, signaling proteins and cell adhesion molecules. Furthermore, studies also point to the important roles that interneurons and glial cells in the retina play in regulating RGC axon regeneration.

KW - Axon growth

KW - Axon injury

KW - Axon regeneration

KW - Axon regrowth

KW - Neuronal regeneration

KW - Optic nerve regeneration

KW - PTEN

KW - Retina

KW - Retinal ganglion cells

KW - STAT3

KW - Transcription factors

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DO - 10.1016/B978-0-12-809324-5.23903-5

M3 - Chapter

AN - SCOPUS:85151227047

SN - 9780128054086

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SP - 630

EP - 641

BT - The Senses

PB - Elsevier

ER -

1.38 - Regeneration of Retinal Ganglion Cell Axons

Abstract

Keywords

ASJC Scopus subject areas

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