Research output per year
Research output per year
- 29 results
Search results
-
2024
FOXP1 and KLF2 reciprocally regulate checkpoints of stem-like to effector transition in CAR T cells
Zhu, Z., Lou, G., Teng, X. L., Wang, H., Luo, Y., Shi, W., Yihunie, K., Hao, S., DeGolier, K., Liao, C., Huang, H., Zhang, Q., Fry, T., Wang, T., Yao, C. & Wu, T., Jan 2024, In: Nature immunology. 25, 1, p. 117-128 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Vegfc-expressing cells form heterotopic bone after musculoskeletal injury
Vishlaghi, N., Guo, L., Griswold-Wheeler, D., Sun, Y., Booker, C., Crossley, J. L., Bancroft, A. C., Juan, C., Korlakunta, S., Ramesh, S., Pagani, C. A., Xu, L., James, A. W., Tower, R. J., Dellinger, M. & Levi, B., Apr 23 2024, In: Cell Reports. 43, 4, 114049.Research output: Contribution to journal › Article › peer-review
Open Access -
2023
Cell Competition Shapes Metastatic Latency and Relapse
Kim, K., Huang, H., Parida, P. K., He, L., Marquez-Palencia, M., Reese, T. C., Kapur, P., Brugarolas, J., Brekken, R. A. & Malladi, S., Jan 9 2023, In: Cancer discovery. 13, 1, p. 85-97 13 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function
Fernandes, L. M., Tresemer, J., Zhang, J., Rios, J. J., Scallan, J. P. & Dellinger, M. T., 2023, In: Frontiers in Cell and Developmental Biology. 11, 1276333.Research output: Contribution to journal › Article › peer-review
Open Access -
TWIST2-mediated chromatin remodeling promotes fusion-negative rhabdomyosarcoma
Shah, A. M., Guo, L., Morales, M. G., Jaichander, P., Chen, K., Huang, H., Hernandez, K. C., Xu, L., Bassel-Duby, R., Olson, E. N. & Liu, N., Apr 2023, In: Science Advances. 9, 17, eade8184.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2022
A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis
Chen, X., Huang, J., Yu, C., Liu, J., Gao, W., Li, J., Song, X., Zhou, Z., Li, C., Xie, Y., Kroemer, G., Liu, J., Tang, D. & Kang, R., Dec 2022, In: Nature communications. 13, 1, 6318.Research output: Contribution to journal › Article › peer-review
Open Access35 Scopus citations -
AXL Inhibitor TP-0903 Reduces Metastasis and Therapy Resistance in Pancreatic Cancer
Zhang, Y., Arner, E. N., Rizvi, A., Toombs, J. E., Huang, H., Warner, S. L., Foulks, J. M. & Brekken, R. A., Jan 2022, In: Molecular Cancer Therapeutics. 21, 1, p. 38-47 10 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer
Huang, H., Wang, Z., Zhang, Y., Pradhan, R. N., Ganguly, D., Chandra, R., Murimwa, G., Wright, S., Gu, X., Maddipati, R., Müller, S., Turley, S. J. & Brekken, R. A., Jun 13 2022, In: Cancer Cell. 40, 6, p. 656-673.e7Research output: Contribution to journal › Article › peer-review
Open Access148 Scopus citations -
Targeting TNF-α-producing macrophages activates antitumor immunity in pancreatic cancer via IL-33 signaling
Dixit, A., Sarver, A., Zettervall, J., Huang, H., Zheng, K., Brekken, R. A. & Provenzano, P. P., Nov 22 2022, In: JCI Insight. 7, 22, e153242.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2021
AXL is a key factor for cell plasticity and promotes metastasis in Pancreatic cancer
Du, W., Phinney, N. Z., Huang, H., Wang, Z., Westcott, J., Toombs, J. E., Zhang, Y., Beg, M. S., Wilkie, T. M., Lorens, J. B. & Brekken, R. A., Aug 1 2021, In: Molecular Cancer Research. 19, 8, p. 1412-1421 10 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis
Deng, J., Kang, Y., Cheng, C. C., Li, X., Dai, B., Katz, M. H., Men, T., Kim, M. P., Koay, E. A., Huang, H., Brekken, R. A. & Fleming, J. B., Sep 8 2021, In: JCI Insight. 6, 17, e146133.Research output: Contribution to journal › Article › peer-review
Open Access58 Scopus citations -
Heterozygous mutation of Vegfr3 reduces renal lymphatics without renal dysfunction
Liu, H., Hiremath, C., Patterson, Q., Vora, S., Shang, Z., Jamieson, A. R., Fiolka, R., Dean, K. M., Dellinger, M. T. & Marciano, D. K., Dec 2021, In: Journal of the American Society of Nephrology. 32, 12Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
KRAS-driven model of Gorham-Stout disease effectively treated with trametinib
Homayun-Sepehr, N., McCarter, A. L., Helaers, R., Galant, C., Boon, L. M., Brouillard, P., Vikkula, M. & Dellinger, M. T., Aug 9 2021, In: JCI Insight. 6, 15, e149831.Research output: Contribution to journal › Article › peer-review
Open Access36 Scopus citations -
Location Matters: Profiling Diffuse Type Gastric Cancer at the Single-Cell Level
Huang, H. & Brekken, R. A., Dec 1 2021, In: Clinical Cancer Research. 27, 23, p. 6284-6286 3 p.Research output: Contribution to journal › Article › peer-review
Open Access -
NUPR1 is a critical repressor of ferroptosis
Liu, J., Song, X., Kuang, F., Zhang, Q., Xie, Y., Kang, R., Kroemer, G. & Tang, D., Dec 1 2021, In: Nature communications. 12, 1, 647.Research output: Contribution to journal › Article › peer-review
Open Access125 Scopus citations -
PDK4 dictates metabolic resistance to ferroptosis by suppressing pyruvate oxidation and fatty acid synthesis
Song, X., Liu, J., Kuang, F., Chen, X., Zeh, H. J., Kang, R., Kroemer, G., Xie, Y. & Tang, D., Feb 23 2021, In: Cell Reports. 34, 8, 108767.Research output: Contribution to journal › Article › peer-review
Open Access111 Scopus citations -
VEGFR2 activity on myeloid cells mediates immune suppression in the tumor microenvironment
Zhang, Y., Huang, H., Coleman, M., Ziemys, A., Gopal, P., Kazmi, S. M. & Brekken, R. A., Dec 8 2021, In: JCI Insight. 6, 23, e150735.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
WWTR1(TAZ)-CAMTA1 reprograms endothelial cells to drive epithelioid hemangioendothelioma
Driskill, J. H., Zheng, Y., Wu, B. K., Wang, L., Cai, J., Rakheja, D., Dellinger, M. & Pan, D., Apr 1 2021, In: Genes and Development. 35, 7, p. 495-511 17 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
2020
Beyond Stiffness: Collagen Signaling in Pancreatic Cancer and Pancreas Regeneration
Huang, H. & Brekken, R. A., Aug 2020, In: American Journal of Pathology. 190, 8, p. 1622-1624 3 p.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Bone development and fracture healing is normal in mice that have a defect in the development of the lymphatic system
McCarter, A. L., Khalid, A., Yi, Y., Monroy, M., Zhao, H., Rios, J. J. & Dellinger, M. T., 2020, In: Lymphology. 53, 4, p. 162-171 10 p.Research output: Contribution to journal › Article › peer-review
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Concerted cell and in vivo screen for pancreatic ductal adenocarcinoma (PDA) chemotherapeutics
Layeghi-Ghalehsoukhteh, S., Pal Choudhuri, S., Ocal, O., Zolghadri, Y., Pashkov, V., Niederstrasser, H., Posner, B. A., Kantheti, H. S., Azevedo-Pouly, A. C., Huang, H., Girard, L., MacDonald, R. J., Brekken, R. A. & Wilkie, T. M., Dec 2020, In: Scientific reports. 10, 1, 20662.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Impaired meningeal lymphatic vessel development worsens stroke outcome
Yanev, P., Poinsatte, K., Hominick, D., Khurana, N., Zuurbier, K. R., Berndt, M., Plautz, E. J., Dellinger, M. T. & Stowe, A. M., Feb 1 2020, In: Journal of Cerebral Blood Flow and Metabolism. 40, 2, p. 263-275 13 p.Research output: Contribution to journal › Article › peer-review
Open Access70 Scopus citations -
Lymphatics in bone arise from pre-existing lymphatics
Monroy, M., McCarter, A. L., Hominick, D., Cassidy, N. & Dellinger, M. T., Nov 2020, In: Development (Cambridge). 147, 21, dev184291.Research output: Contribution to journal › Article › peer-review
Open Access15 Scopus citations -
Recent advances in understanding cancer-associated fibroblasts in pancreatic cancer
Huang, H. & Brekken, R. A., Aug 2020, In: American Journal of Physiology - Cell Physiology. 319, 2, p. C233-C243Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2019
2-Amino-2,3-dihydro-1 H-indene-5-carboxamide-Based Discoidin Domain Receptor 1 (DDR1) Inhibitors: Design, Synthesis, and in Vivo Antipancreatic Cancer Efficacy
Zhu, D., Huang, H., Pinkas, D. M., Luo, J., Ganguly, D., Fox, A. E., Arner, E., Xiang, Q., Tu, Z. C., Bullock, A. N., Brekken, R. A., Ding, K. & Lu, X., Aug 22 2019, In: Journal of Medicinal Chemistry. 62, 16, p. 7431-7444 14 p.Research output: Contribution to journal › Article › peer-review
Open Access42 Scopus citations -
Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution
Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E., Verma, U. & Brekken, R. A., Jul 23 2019, In: JCI Insight. 4, 16, e129212.Research output: Contribution to journal › Article › peer-review
Open Access182 Scopus citations -
Cyclooxygenase-2 inhibition potentiates the efficacy of vascular endothelial growth factor blockade and promotes an immune stimulatory microenvironment in preclinical models of pancreatic cancer
Zhang, Y., Kirane, A., Huang, H., Sorrelle, N. B., Burrows, F. J., Dellinger, M. T. & Brekken, R. A., Feb 2019, In: Molecular Cancer Research. 17, 2, p. 348-355 8 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly
Rodriguez‑Laguna, L., Agra, N., Ibañez, K., Oliva‑Molina, G., Gordo, G., Khurana, N., Hominick, D., Beato, M., Colmenero, I., Herranz, G., Torres Canizalez, J. M., Pena, R. R., Vallespín, E., Martín‑Arenas, R., Del Pozo, Á., Villaverde, C., Bustamante, A., Ayuso, C., Lapunzina, P., Lopez‑Gutierrez, J. C., & 2 others, Feb 1 2019, In: Journal of Experimental Medicine. 216, 2, p. 407-418 12 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Scopus citations -
Targeting TGFβR2-mutant tumors exposes vulnerabilities to stromal TGFβ blockade in pancreatic cancer
Huang, H., Zhang, Y., Gallegos, V., Sorrelle, N., Zaid, M. M., Toombs, J., Du, W., Wright, S., Hagopian, M., Wang, Z., Hosein, A. N., Sathe, A. A., Xing, C., Koay, E. J., Driscoll, K. E. & Brekken, R. A., Nov 7 2019, In: EMBO Molecular Medicine. 11, 11, e10515.Research output: Contribution to journal › Article › peer-review
Open Access52 Scopus citations