Physiology - Division H – Research output — University of Texas Southwestern Medical Center

2023

Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel

Zhang, J., Zeng, W., Han, Y., Lee, W. R., Liou, J. & Jiang, Y., Jul 20 2023, In: Molecular cell. 83, 14, p. 2524-2539.e7

Research output: Contribution to journal › Article › peer-review

Open Access

10 Scopus citations

Structural mechanisms of the human cardiac sodium-calcium exchanger NCX1

Xue, J., Zeng, W., Han, Y., John, S., Ottolia, M. & Jiang, Y., Dec 2023, In: Nature communications. 14, 1, 6181.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

2022

Structural biology of cation channels important for lysosomal calcium release

Gan, N. & Jiang, Y., Jan 2022, In: Cell Calcium. 101, 102519.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Scopus citations

Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P2 and rapamycin

Gan, N., Han, Y., Zeng, W., Wang, Y., Xue, J. & Jiang, Y., Feb 15 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 7, e2120404119.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Scopus citations

Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel

Xue, J., Han, Y., Zeng, W. & Jiang, Y., Jan 5 2022, In: Neuron. 110, 1, p. 86-95.e5

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

2021

Structural mechanisms of gating and selectivity of human rod CNGA1 channel

Xue, J., Han, Y., Zeng, W., Wang, Y. & Jiang, Y., Apr 21 2021, In: Neuron. 109, 8, p. 1302-1313.e4

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Tmem120a is a coenzyme a-binding membrane protein with structural similarities to elovl fatty acid elongase

Xue, J., Han, Y., Baniasadi, H., Zeng, W., Pei, J., Grishin, N. V., Wang, J., Tu, B. P. & Jiang, Y., 2021, In: eLife. 10, e71220.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

Voltage-gating and cytosolic Ca²⁺ activation mechanisms of arabidopsis two-pore channel AtTPC1

Ye, F., Xu, L., Li, X., Zeng, W., Gan, N., Zhao, C., Yang, W., Jiang, Y. & Guo, J., Dec 7 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 49, e2113946118.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

2020

Cryo-EM structures of human ZnT8 in both outward-and inward-facing conformations

Xue, J., Xie, T., Zeng, W., Jiang, Y. & Bai, X. C., Jul 2020, In: eLife. 9, p. 1-32 32 p., e58823.

Research output: Contribution to journal › Article › peer-review

Open Access

40 Scopus citations

Structural insights into the ca²⁺-dependent gating of the human mitochondrial calcium uniporter

Wang, Y., Han, Y., She, J., Nguyen, N. X., Mootha, V. K., Bai, X. C. & Jiang, Y., Aug 2020, In: eLife. 9, p. 1-19 19 p., e60513.

Research output: Contribution to journal › Article › peer-review

Open Access

32 Scopus citations

2019

Ca²⁺-regulated Ca²⁺ channels with an RCK gating ring control plant symbiotic associations

Kim, S., Zeng, W., Bernard, S., Liao, J., Venkateshwaran, M., Ane, J. M. & Jiang, Y., Dec 1 2019, In: Nature communications. 10, 1, 3703.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Structural and functional characterization of an otopetrin family proton channel

Chen, Q., Zeng, W., She, J., Bai, X. C. & Jiang, Y., 2019, In: eLife. 8, e46710.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

Structural Mechanism of EMRE-Dependent Gating of the Human Mitochondrial Calcium Uniporter

Wang, Y., Nguyen, N. X., She, J., Zeng, W., Yang, Y., Bai, X. C. & Jiang, Y., May 16 2019, In: Cell. 177, 5, p. 1252-1261.e13

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

Structural mechanisms of phospholipid activation of the human TPC2 channel

She, J., Zeng, W., Guo, J., Chen, Q., Bai, X. C. & Jiang, Y., Mar 2019, In: eLife. 8, e45222.

Research output: Contribution to journal › Article › peer-review

Open Access

86 Scopus citations

2018

Cryo-EM structure of a fungal mitochondrial calcium uniporter

Nguyen, N. X., Armache, J. P., Lee, C., Yang, Y., Zeng, W., Mootha, V. K., Cheng, Y., Bai, X. C. & Jiang, Y., Jul 26 2018, In: Nature. 559, 7715, p. 570-574 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

108 Scopus citations

Structural insights into the voltage and phospholipid activation of the mammalian TPC1 channel

She, J., Guo, J., Chen, Q., Zeng, W., Jiang, Y. & Bai, X. C., Apr 5 2018, In: Nature. 556, 7699, p. 130-134 5 p.

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

2017

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs

Chen, Q., She, J., Zeng, W., Guo, J., Xu, H., Bai, X. C. & Jiang, Y., Oct 19 2017, In: Nature. 550, 7676, 24035.

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Structures of the calcium-activated, non-selective cation channel TRPM4

Guo, J., She, J., Zeng, W., Chen, Q., Bai, X. C. & Jiang, Y., Dec 14 2017, In: Nature. 552, 7684, p. 205-209 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

136 Scopus citations

The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture

Lee, C., Guo, J., Zeng, W., Kim, S., She, J., Cang, C., Ren, D. & Jiang, Y., Jul 27 2017, In: Nature. 547, 7664, p. 472-475 4 p.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

Tuning the ion selectivity of two-pore channels

Guo, J., Zeng, W. & Jiang, Y., Jan 31 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 5, p. 1009-1014 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

83 Scopus citations

2016

Electrophysiological characterization of the archaeal transporter NCX_Mj using solid supported membrane technology

Barthmes, M., Liao, J., Jiang, Y., Brüggemann, A. & Wahl-Schott, C., 2016, In: Journal of General Physiology. 147, 6, p. 485-496 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger

Liao, J., Marinelli, F., Lee, C., Huang, Y., Faraldo-Gómez, J. D. & Jiang, Y., Jun 7 2016, In: Nature Structural and Molecular Biology. 23, 6, p. 590-599 10 p.

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Structure of the voltage-gated two-pore channel TPC1 from Arabidopsis thaliana

Guo, J., Zeng, W., Chen, Q., Lee, C., Chen, L., Yang, Y., Cang, C., Ren, D. & Jiang, Y., Mar 10 2016, In: Nature. 531, 7593, p. 196-201 6 p.

Research output: Contribution to journal › Article › peer-review

188 Scopus citations

2015

Structural and mechanistic roles of novel chemical ligands on the SdiA quorum-sensing transcription regulator

Nguyen, Y., Nguyen, N. X., Rogers, J. L., Liao, J., Macmillan, J. B., Jiang, Y. & Sperandio, V., Mar 31 2015, In: mBio. 6, 2, e02429-14.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Structural implications of weak Ca²⁺ block in Drosophila cyclic nucleotide-gated channels

Lam, Y. L., Zeng, W., Derebe, M. G. & Jiang, Y., Sep 1 2015, In: Journal of General Physiology. 146, 3, p. 255-263 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

2014

A motif in LILRB2 critical for Angptl2 binding and activation

Deng Ph.D., M., Lu, Z., Zheng, J., Wan, X., Chen, X., Hirayasu, K., Sun, H., Lam, Y., Chen, L., Wang, Q., Song, C., Huang, N., Gao, G. F., Jiang, Y., Arase, H. & Zhang, C., Aug 7 2014, In: Blood. 124, 6, p. 924-935 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

66 Scopus citations

A Protein Kinase C Phosphorylation Motif in GLUT1 Affects Glucose Transport and is Mutated in GLUT1 Deficiency Syndrome

Lee, E. E., Ma, J., Sacharidou, A., Mi, W., Salato, V. K., Nguyen, N., Jiang, Y., Pascual, J. M., North, P. E., Shaul, P. W., Mettlen, M. & Wang, R. C., Nov 24 2014, In: Molecular cell. 58, 5, p. 845-853 9 p.

Research output: Contribution to journal › Article › peer-review

97 Scopus citations

Lipopolysaccharide assembly in the bacterial outer membrane revealed by X-ray crystallography

Jiang, Y. X., Sep 1 2014, In: Science China. Life sciences. 57, 9, p. 954-956 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

The conserved potassium channel filter can have distinct ion binding profiles: Structural analysis of rubidium, cesium, and barium binding in NaK2K

Lam, Y. L., Zeng, W., Sauer, D. B. & Jiang, Y., 2014, In: Journal of General Physiology. 144, 2, p. 181-192 12 p.

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

2013

Sodium and potassium competition in potassium-selective and non-selective channels

Sauer, D. B., Zeng, W., Canty, J., Lam, Y. & Jiang, Y., 2013, In: Nature communications. 4, 2721.

Research output: Contribution to journal › Article › peer-review

50 Scopus citations

The cardiac Na⁺-Ca²⁺ exchanger has two cytoplasmic ion permeation pathways

John, S. A., Liao, J., Jiang, Y. & Ottolia, M., Apr 30 2013, In: Proceedings of the National Academy of Sciences of the United States of America. 110, 18, p. 7500-7505 6 p.

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

2012

Distinct gating mechanisms revealed by the structures of a multi-ligand gated K⁺ channel

Kong, C., Zeng, W., Ye, S., Chen, L., Sauer, D. B., Lam, Y., Derebe, M. G. & Jiang, Y., Dec 13 2012, In: eLife. 2012, 1, e00184.

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Structural insight into the ion-exchange mechanism of the sodium/calcium exchanger

Liao, J., Li, H., Zeng, W., Sauer, D. B., Belmares, R. & Jiang, Y., Feb 10 2012, In: Science. 335, 6069, p. 686-690 5 p.

Research output: Contribution to journal › Article › peer-review

211 Scopus citations

2011

Crucial points within the pore as Determinants of K⁺ channel conductance and gating

Shi, N., Zeng, W., Ye, S., Li, Y. & Jiang, Y., Aug 5 2011, In: Journal of Molecular Biology. 411, 1, p. 27-35 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Crystal structure of a potassium ion transporter, TrkH

Cao, Y., Jin, X., Huang, H., Derebe, M. G., Levin, E. J., Kabaleeswaran, V., Pan, Y., Punta, M., Love, J., Weng, J., Quick, M., Ye, S., Kloss, B., Bruni, R., Martinez-Hackert, E., Hendrickson, W. A., Rost, B., Javitch, J. A., Rajashankar, K. R., Jiang, Y., & 1 othersZhou, M., Mar 17 2011, In: Nature. 471, 7338, p. 336-341 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

111 Scopus citations

Protein interactions central to stabilizing the K ⁺ channel selectivity filter in a four-sited configuration for selective K ⁺ permeation

Sauer, D. B., Zenga, W., Raghunathan, S. & Jiang, Y., Oct 4 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 40, p. 16634-16639 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Structural studies of ion permeation and Ca²⁺ blockage of a bacterial channel mimicking the cyclic nucleotide-gated channel pore

Derebe, M. G., Zeng, W., Li, Y., Alam, A. & Jiang, Y., Jan 11 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 2, p. 592-597 6 p.

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Structural studies of ion selectivity in tetrameric cation channels

Alam, A. & Jiang, Y., May 2011, In: Journal of General Physiology. 137, 5, p. 397-403 7 p.

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites

Derebe, M. G., Sauer, D. B., Zeng, W., Alam, A., Shia, N. & Jiang, Y., Jan 11 2011, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 2, p. 598-602 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

96 Scopus citations

2010

Novel insights into K⁺ selectivity from high-resolution structures of an open K⁺ channel pore

Ye, S., Li, Y. & Jiang, Y., Aug 2010, In: Nature Structural and Molecular Biology. 17, 8, p. 1019-1023 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

118 Scopus citations

S. aureus MscL is a pentamer in vivo but of variable stoichiometries in vitro: Implications for detergent- solubilized membrane proteins

Dorwart, M. R., Wray, R., Brautigam, C. A., Jiang, Y. & Blount, P., Dec 2010, In: PLoS biology. 8, 12, e1000555.

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Semisynthesis of NaK, a Na⁺ and K⁺ conducting ion channel

Linn, K. M., Derebe, M. G., Jiang, Y. & Valiyaveetil, F. I., Jun 1 2010, In: Biochemistry. 49, 21, p. 4450-4456 7 p.

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Structure of the gating ring from the human large-conductance Ca 2+-gated K⁺ channel

Wu, Y., Yang, Y., Ye, S. & Jiang, Y., Jul 15 2010, In: Nature. 466, 7304, p. 393-397 5 p.

Research output: Contribution to journal › Article › peer-review

177 Scopus citations

2009

High-resolution structure of the open NaK channel

Alam, A. & Jiang, Y., Jan 2009, In: Nature Structural and Molecular Biology. 16, 1, p. 30-34 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

111 Scopus citations

Structural analysis of ion selectivity in the NaK channel

Alam, A. & Jiang, Y., Jan 2009, In: Nature Structural and Molecular Biology. 16, 1, p. 35-41 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

81 Scopus citations

2007

Gating and inward rectifying properties of the MthK K⁺ channel with and without the gating ring

Li, Y., Berke, I., Chen, L. & Jiang, Y., Feb 2007, In: Journal of General Physiology. 129, 2, p. 109-120 12 p.

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Structural insight into Ca²⁺ specificity in tetrameric cation channels

Alam, A., Shi, N. & Jiang, Y., Sep 25 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 39, p. 15334-15339 6 p.

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

2006

Atomic structure of a Na⁺- and K⁺-conducting channel

Shi, N., Ye, S., Alam, A., Chen, L. & Jiang, Y., Mar 23 2006, In: Nature. 440, 7083, p. 570-574 5 p.

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Crystal Structures of a Ligand-free MthK Gating Ring: Insights into the Ligand Gating Mechanism of K⁺ Channels

Ye, S., Li, Y., Chen, L. & Jiang, Y., Sep 22 2006, In: Cell. 126, 6, p. 1161-1173 13 p.

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

2005

Structural of the MthK RCK domain and the effect of Ca²⁺ on gating ring stability

Dong, J., Shi, N., Berke, I., Chen, L. & Jiang, Y., Dec 16 2005, In: Journal of Biological Chemistry. 280, 50, p. 41716-41724 9 p.

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Physiology - Division H

Research output

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