Research output per year
Research output per year
Search results
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2024
A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells
Xu, S., Smothers, J. C., Rye, D., Endapally, S., Chen, H., Li, S., Liang, G., Kinnebrew, M., Rohatgi, R., Posner, B. A. & Radhakrishnan, A., Feb 13 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 7, p. e2318024121Research output: Contribution to journal › Article › peer-review
Open Access -
2023
A Concerted Mechanism Involving ACAT and SREBPs By which Oxysterols Deplete Accessible Cholesterol To Restrict Microbial Infection
Heisler, D. B., Johnson, K. A., Ma, D., Ohlson, M. B., Zhang, L., Tran, M., Corley, C. D., Abrams, M. E., McDonald, J. G., Schoggins, J. W., Alto, N. M. & Radhakrishnan, A., Jan 2023, In: eLife. 12, e83534.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2021
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
Kinnebrew, M., Luchetti, G., Sircar, R., Frigui, S., Viti, L. V., Naito, T., Beckert, F., Saheki, Y., Siebold, C., Radhakrishnan, A. & Rohatgi, R., Oct 2021, In: eLife. 10, e70504.Research output: Contribution to journal › Article › peer-review
Open Access25 Scopus citations -
Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing
Kober, D. L., Radhakrishnan, A., Goldstein, J. L., Brown, M. S., Clark, L. D., Bai, X. C. & Rosenbaum, D. M., Jul 8 2021, In: Cell. 184, 14, p. 3689-3701.e22Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2020
Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis
Wang, X., Cai, B., Yang, X., Sonubi, O. O., Zheng, Z., Ramakrishnan, R., Shi, H., Valenti, L., Pajvani, U. B., Sandhu, J., Infante, R. E., Radhakrishnan, A., Covey, D. F., Guan, K. L., Buck, J., Levin, L. R., Tontonoz, P., Schwabe, R. F. & Tabas, I., May 5 2020, In: Cell Metabolism. 31, 5, p. 969-986.e7Research output: Contribution to journal › Article › peer-review
Open Access103 Scopus citations -
Identification of a degradation signal at the carboxy terminus of SREBP2: A new role for this domain in cholesterol homeostasis
Kober, D. L., Xu, S., Li, S., Bajaj, B., Liang, G., Rosenbaum, D. M. & Radhakrishnan, A., Nov 10 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 45, p. 28080-28091 12 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Oxysterols provide innate immunity to bacterial infection by mobilizing cell surface accessible cholesterol
Abrams, M. E., Johnson, K. A., Perelman, S. S., Zhang, L. S., Endapally, S., Mar, K. B., Thompson, B. M., McDonald, J. G., Schoggins, J. W., Radhakrishnan, A. & Alto, N. M., Jul 1 2020, In: Nature microbiology. 5, 7, p. 929-942 14 p.Research output: Contribution to journal › Article › peer-review
Open Access85 Scopus citations -
2019
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
Kinnebrew, M., Iverson, E. J., Patel, B. B., Pusapati, G. V., Kong, J. H., Johnson, K. A., Luchetti, G., Eckert, K. M., McDonald, J. G., Covey, D. F., Siebold, C., Radhakrishnan, A. & Rohatgi, R., Oct 2019, In: eLife. 8, e50051.Research output: Contribution to journal › Article › peer-review
Open Access89 Scopus citations -
Ostreolysin A and anthrolysin O use different mechanisms to control movement of cholesterol from the plasma membrane to the endoplasmic reticulum
Johnson, K. A., Endapally, S., Vazquez, D. C., Infante, R. E. & Radhakrishnan, A., Nov 15 2019, In: Journal of Biological Chemistry. 294, 46, p. 17289-17300 12 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Scopus citations