Research output per year
Research output per year
- 1 - 50 out of 158 results
Search results
-
2023
Biophysical and biochemical studies support TP0094 as a phosphotransacetylase in an acetogenic energy-conservation pathway in Treponema pallidum
Brautigam, C. A., Deka, R. K., Tso, S. C., Liu, W. Z. & Norgard, M. V., May 2023, In: PloS one. 18, 5 May, e0283952.Research output: Contribution to journal › Article › peer-review
Open Access -
2022
Inhibition of bacterial FMN transferase: A potential avenue for countering antimicrobial resistance
Deka, R. K., Deka, A., Liu, W. Z., Norgard, M. V. & Brautigam, C. A., Feb 2022, In: Protein Science. 31, 2, p. 545-551 7 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2021
An rfuABCD-like operon and its relationship to riboflavin utilization and mammalian infectivity by Borrelia burgdorferi
Muramatsu, M. K., Zhou, J., Fitzgerald, B. L., Deka, R. K., Belisle, J. T. & Norgard, M. V., Oct 2021, In: Infection and immunity. 89, 10, e00307-21.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2020
Biophysical and biochemical characterization of tp0037, a d-lactate dehydrogenase, supports an acetogenic energy conservation pathway in treponema pallidum
Deka, R. K., Liu, W. Z., Norgard, M. V. & Brautigam, C. A., Sep 1 2020, In: mBio. 11, 5, p. 1-17 17 p., e02249-20.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
Using modern approaches to sedimentation velocity to detect conformational changes in proteins
Brautigam, C. A., Tso, S. C., Deka, R. K., Liu, W. Z. & Norgard, M. V., Dec 2020, In: European Biophysics Journal. 49, 8, p. 729-743 15 p.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations -
2018
Biophysical insights into a highly selective l-arginine-binding lipoprotein of a pathogenic treponeme
Deka, R. K., Liu, W. Z., Tso, S. C., Norgard, M. V. & Brautigam, C. A., Dec 2018, In: Protein Science. 27, 12, p. 2037-2050 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Crystal stuctures of MglB-2 (TP0684), a topologically variant d-glucose-binding protein from Treponema pallidum, reveal a ligand-induced conformational change
Brautigam, C. A., Deka, R. K., Liu, W. Z. & Norgard, M. V., Apr 2018, In: Protein Science. 27, 4, p. 880-885 6 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
MyD88 signaling in T cells is critical for effector CD4 T cell differentiation following a transitional T follicular helper cell stage
Mandraju, R., Jain, A., Gao, Y., Ouyang, Z., Norgard, M. V. & Pasare, C., May 1 2018, In: Infection and immunity. 86, 5, e00791-17.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
2017
Functional clues from the crystal structure of an orphan periplasmic ligand-binding protein from Treponema pallidum
Brautigam, C. A., Deka, R. K., Liu, W. Z., Tomchick, D. R. & Norgard, M. V., Apr 1 2017, In: Protein Science. 26, 4, p. 847-856 10 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
The putative Walker A and Walker B motifs of Rrp2 are required for the growth of Borrelia burgdorferi
Ouyang, Z. & Zhou, J., Jan 1 2017, In: Molecular Microbiology. 103, 1, p. 86-98 13 p.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
2016
Evidence that BosR (BB0647) is a positive autoregulator in Borrelia burgdorferi
Ouyang, Z., Zhou, J. & Norgard, M. V., 2016, In: Infection and immunity. 84, 9, p. 2566-2574 9 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations -
Molecular insights into the enzymatic diversity of flavin-trafficking protein (Ftp; formerly ApbE) in flavoprotein biogenesis in the bacterial periplasm
Deka, R. K., Brautigam, C. A., Liu, W. Z., Tomchick, D. R. & Norgard, M. V., Feb 1 2016, In: MicrobiologyOpen. 5, 1, p. 21-38 18 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Scopus citations -
The Tp0684 (MglB-2) lipoprotein of treponema pallidum: A glucose-binding protein with divergent topology
Brautigam, C. A., Deka, R. K., Liu, W. Z. & Norgard, M. V., Aug 2016, In: PloS one. 11, 8, e0161022.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2015
BadR (BB0693) controls growth phase-dependent induction of rpoS and bosR in Borrelia burgdorferi via recognizing TAAAATAT motifs
Ouyang, Z. & Zhou, J., Dec 1 2015, In: Molecular Microbiology. 98, 6, p. 1147-1167 21 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Evidence for posttranslational protein flavinylation in the syphilis spirochete treponema pallidum: Structural and biochemical insights from the catalytic core of a periplasmic flavin-trafficking protein
Deka, R. K., Brautigam, C. A., Liu, W. Z., Tomchick, D. R. & Norgard, M. V., May 5 2015, In: mBio. 6, 3, p. 1-9 9 p., e00519-15.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Insights into the potential function and membrane organization of the TP0435 (Tp17) lipoprotein from Treponema pallidum derived from structural and biophysical analyses
Brautigam, C. A., Deka, R. K., Liu, W. Z. & Norgard, M. V., Jan 1 2015, In: Protein Science. 24, 1, p. 11-19 9 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
2014
CsrA (BB0184) is not involved in activation of the RpoN-RpoS regulatory pathway in Borrelia burgdorferi
Ouyang, Z., Zhou, J. & Norgard, M. V., Apr 2014, In: Infection and immunity. 82, 4, p. 1511-1522 12 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Scopus citations -
FTT0831c/FTL_0325 contributes to Francisella tularensis cell division, maintenance of cell shape, and structural integrity
Robertson, G. T., Russo Case, E. D., Dobbs, N., Ingle, C., Balaban, M., Celli, J. & Norgard, M. V., Jul 2014, In: Infection and immunity. 82, 7, p. 2935-2948 14 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Scopus citations -
Identification of a core sequence for the binding of BosR to the rpoS promoter region in Borrelia burgdorferi
Ouyang, Z., Zhou, J., Brautigam, C. A., Deka, R. & Norgard, M. V., May 2014, In: Microbiology (United Kingdom). 160, PART 5, p. 851-862 12 p.Research output: Contribution to journal › Article › peer-review
15 Scopus citations -
Sequence, biophysical, and structural analyses of the PstS lipoprotein (BB0215) from Borrelia burgdorferi reveal a likely binding component of an ABC-type phosphate transporter
Brautigam, C. A., Ouyang, Z., Deka, R. K. & Norgard, M. V., Feb 2014, In: Protein Science. 23, 2, p. 200-212 13 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
Synthesis of RpoS is dependent on a putative enhancer binding protein Rrp2 in Borrelia burgdorferi
Ouyang, Z., Zhou, J. & Norgard, M. V., May 8 2014, In: PloS one. 9, 5, e96917.Research output: Contribution to journal › Article › peer-review
19 Scopus citations -
2013
Evidence for an ABC-type riboflavin transporter system in pathogenic spirochetes
Deka, R. K., Brautigam, C. A., Biddy, B. A., Liu, W. Z. & Norgard, M. V., 2013, In: mBio. 4, 1, e00615-12.Research output: Contribution to journal › Article › peer-review
38 Scopus citations -
IglE is an outer membrane-associated lipoprotein essential for intracellular survival and murine virulence of type A francisella tularensis
Robertson, G. T., Child, R., Ingle, C., Celli, J. & Norgard, M. V., Nov 2013, In: Infection and immunity. 81, 11, p. 4026-4040 15 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Scopus citations -
Purification, crystallization and preliminary X-ray analysis of TP0435 (Tp17) from the syphilis spirochete Treponema pallidum
Brautigam, C. A., Deka, R. K. & Norgard, M. V., Apr 2013, In: Acta Crystallographica Section F: Structural Biology and Crystallization Communications. 69, 4, p. 453-455 3 p.Research output: Contribution to journal › Article › peer-review
Open Access4 Scopus citations -
The TP0796 lipoprotein of Treponema pallidum is a bimetal-dependent FAD pyrophosphatase with a potential role in flavin homeostasis
Deka, R. K., Brautigam, C. A., Liu, W. Z., Tomchick, D. R. & Norgard, M. V., Apr 19 2013, In: Journal of Biological Chemistry. 288, 16, p. 11106-11121 16 p.Research output: Contribution to journal › Article › peer-review
23 Scopus citations -
2012
Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi
Ouyang, Z., Narasimhan, S., Neelakanta, G., Kumar, M., Pal, U., Fikrig, E. & Norgard, M. V., 2012, In: BMC microbiology. 12, 44.Research output: Contribution to journal › Article › peer-review
52 Scopus citations -
Biophysical and bioinformatic analyses implicate the treponema pallidum tp34 lipoprotein (tp0971) in transition metal homeostasis
Brautigam, C. A., Deka, R. K., Ouyang, Z., Machius, M., Knutsen, G., Tomchick, D. R. & Norgard, M. V., Oct 2012, In: Journal of bacteriology. 194, 24, p. 6771-6781 11 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
Structural, bioinformatic, and in vivo analyses of two treponema pallidum Lipoproteins reveal a unique TRAP transporter
Deka, R. K., Brautigam, C. A., Goldberg, M., Schuck, P., Tomchick, D. R. & Norgard, M. V., Mar 9 2012, In: Journal of Molecular Biology. 416, 5, p. 678-696 19 p.Research output: Contribution to journal › Article › peer-review
Open Access27 Scopus citations -
Structural and thermodynamic characterization of the interaction between two periplasmic Treponema pallidum lipoproteins that are components of a TPR-protein-associated TRAP transporter (TPAT)
Brautigam, C. A., Deka, R. K., Schuck, P., Tomchick, D. R. & Norgard, M. V., Jun 29 2012, In: Journal of Molecular Biology. 420, 1-2, p. 70-86 17 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations -
2011
BosR (BB0647) controls the RpoN-RpoS regulatory pathway and virulence expression in Borrelia burgdorferi by a novel DNA-binding mechanism
Ouyang, Z., Deka, R. K. & Norgard, M. V., Feb 2011, In: PLoS pathogens. 7, 2, e1001272.Research output: Contribution to journal › Article › peer-review
90 Scopus citations -
Cyclic di-gmp is essential for the survival of the lyme disease spirochete in ticks
He, M., Ouyang, Z., Troxell, B., Xu, H., Moh, A., Piesman, J., Norgard, M. V., Gomelsky, M. & Yang, X. F., Jun 2011, In: PLoS pathogens. 7, 6, e1002133.Research output: Contribution to journal › Article › peer-review
101 Scopus citations -
2010
Analysis of the dbpBA upstream regulatory region controlled by RpoS in Borrelia burgdorferi
Ouyang, Z., Haq, S. & Norgard, M. V., Apr 2010, In: Journal of bacteriology. 192, 7, p. 1965-1974 10 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Determination of protein complex stoichiometry through multisignal sedimentation velocity experiments
Padrick, S. B., Deka, R. K., Chuang, J. L., Wynn, R. M., Chuang, D. T., Norgard, M. V., Rosen, M. K. & Brautigam, C. A., Dec 2010, In: Analytical biochemistry. 407, 1, p. 89-103 15 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Invariant NKT cell development requires a full complement of functional CD3 ζ immunoreceptor tyrosine-based activation motifs
Becker, A. M., Blevins, J. S., Tomson, F. L., Eitson, J. L., Medeiros, J. J., Yarovinsky, F., Norgard, M. V. & Van Oers, N. S. C., Jun 15 2010, In: Journal of Immunology. 184, 12, p. 6822-6832 11 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
Method for the isolation of Francisella tularensis outer membranes
Huntley, J. F., Robertson, G. T. & Norgard, M. V., Jun 2010, In: Journal of Visualized Experiments. 40, e2044.Research output: Contribution to journal › Article › peer-review
Open Access9 Scopus citations -
2009
A manganese transporter, BB0219 (BmtA), is required for virulence by the Lyme disease spirochete, Borrelia burgdorferi
Ouyang, Z., He, M., Oman, T., Yang, X. F. & Norgard, M. V., Mar 3 2009, In: Proceedings of the National Academy of Sciences of the United States of America. 106, 9, p. 3449-3454 6 p.Research output: Contribution to journal › Article › peer-review
Open Access72 Scopus citations -
BosR (BB0647) governs virulence expression in Borrelia burgdorferi
Ouyang, Z., Kumar, M., Kariu, T., Haq, S., Goldberg, M., Pal, U. & Norgard, M. V., Dec 2009, In: Molecular Microbiology. 74, 6, p. 1331-1343 13 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Scopus citations -
Rrp2, a σ 54-dependent transcriptional activator of Borrelia burgdorferi, activates rpoS in an enhancer-independent manner
Blevins, J. S., Xu, H., He, M., Norgard, M. V., Reitzer, L. & Yang, X. F., Apr 2009, In: Journal of bacteriology. 191, 8, p. 2902-2905 4 p.Research output: Contribution to journal › Article › peer-review
46 Scopus citations -
The effect of progesterone levels and pregnancy on HIV-1 coreceptor expression
Sheffield, J. S., Wendel, G. D., McIntire, D. D. & Norgard, M. V., Jan 2009, In: Reproductive Sciences. 16, 1, p. 20-31 12 p.Research output: Contribution to journal › Article › peer-review
61 Scopus citations -
2008
Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi
He, M., Oman, T., Xu, H., Blevins, J., Norgard, M. V. & Yang, X. F., Dec 2008, In: Molecular Microbiology. 70, 6, p. 1453-1464 12 p.Research output: Contribution to journal › Article › peer-review
Open Access29 Scopus citations -
Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infection
Blevins, J. S., Hagman, K. E. & Norgard, M. V., 2008, In: BMC microbiology. 8, 82.Research output: Contribution to journal › Article › peer-review
90 Scopus citations -
Characterization of fig operon mutants of Francisella novicida U112
Kiss, K., Liu, W., Huntley, J. F., Norgard, M. V. & Hansen, E. J., Aug 2008, In: FEMS Microbiology Letters. 285, 2, p. 270-277 8 p.Research output: Contribution to journal › Article › peer-review
37 Scopus citations -
Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi
Yang, X. F., Goldberg, M. S., He, M., Xu, H., Blevins, J. S. & Norgard, M. V., Oct 2008, In: Infection and immunity. 76, 10, p. 4439-4444 6 p.Research output: Contribution to journal › Article › peer-review
Open Access19 Scopus citations -
Essential role of the response regulator Rrp2 in the infectious cycle of Borrelia burgdorferi
Boardman, B. K., He, M., Ouyang, Z., Xu, H., Pang, X. & Yang, X. F., Sep 2008, In: Infection and immunity. 76, 9, p. 3844-3853 10 p.Research output: Contribution to journal › Article › peer-review
Open Access95 Scopus citations -
Native outer membrane proteins protect mice against pulmonary challenge with virulent type A Francisella tularensis
Huntley, J. F., Conley, P. G., Rasko, D. A., Hagman, K. E., Apicella, M. A. & Norgard, M. V., Aug 2008, In: Infection and immunity. 76, 8, p. 3664-3671 8 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi
Ouyang, Z., Blevins, J. S. & Norgard, M. V., 2008, In: Microbiology. 154, 9, p. 2641-2658 18 p.Research output: Contribution to journal › Article › peer-review
103 Scopus citations -
2007
Adaptation of a luciferase gene reporter and lac expression system to Borrelia burgdorferi
Blevins, J. S., Revel, A. T., Smith, A. H., Bachlani, G. N. & Norgard, M. V., Mar 2007, In: Applied and environmental microbiology. 73, 5, p. 1501-1513 13 p.Research output: Contribution to journal › Article › peer-review
Open Access68 Scopus citations -
Assessment of cell-surface exposure and vaccinogenic potentials of Treponema pallidum candidate outer membrane proteins
Tomson, F. L., Conley, P. G., Norgard, M. V. & Hagman, K. E., Sep 2007, In: Microbes and Infection. 9, 11, p. 1267-1275 9 p.Research output: Contribution to journal › Article › peer-review
17 Scopus citations -
Characterization of Francisella tularensis outer membrane proteins
Huntley, J. F., Conley, P. G., Hagman, K. E. & Norgard, M. V., Jan 2007, In: Journal of bacteriology. 189, 2, p. 561-574 14 p.Research output: Contribution to journal › Article › peer-review
Open Access89 Scopus citations -
Crystal structure of the Tp34 (TP0971) lipoprotein of Treponema pallidum: Implications of its metal-bound state and affinity for human lactoferrin
Deka, R. K., Brautigam, C. A., Tomson, F. L., Lumpkins, S. B., Tomchick, D. R., Machius, M. & Norgard, M. V., Feb 23 2007, In: Journal of Biological Chemistry. 282, 8, p. 5944-5958 15 p.Research output: Contribution to journal › Article › peer-review
44 Scopus citations