Int Med - Autophagy Rsrch Ctr – Research output — University of Texas Southwestern Medical Center

2024

Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer

Bennett, L., Jaiswal, P. K., Harkless, R. V., Long, T. M., Gao, N., Vandenburg, B., Selman, P., Durdana, I., Lastra, R. R., Vander Griend, D., Adelaiye-Ogala, R., Szmulewitz, R. Z. & Conzen, S. D., Apr 2 2024, In: Molecular Cancer Therapeutics. 23, 4, p. 552-563 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2023

BECN1^F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner

Sebti, S., Zou, Z. & Shiloh, M. U., 2023, In: Autophagy. 19, 3, p. 957-965 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

2021

BAG6 promotes PINK1 signaling pathway and is essential for mitophagy

Ragimbeau, R., El Kebriti, L., Sebti, S., Fourgous, E., Boulahtouf, A., Arena, G., Espert, L., Turtoi, A., Gongora, C., Houédé, N. & Pattingre, S., Feb 2021, In: FASEB Journal. 35, 2, e21361.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Scopus citations

Enhanced autophagy in Becn1^F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction

Wang, C., Haas, M., Yeo, S. K., Sebti, S., Fernández, Á. F., Zou, Z., Levine, B. & Guan, J. L., 2021, (Accepted/In press) In: Autophagy.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

GLIPR2 is a negative regulator of autophagy and the BECN1-ATG14-containing phosphatidylinositol 3-kinase complex

Zhao, Y., Zou, Z., Sun, D., Li, Y., Sinha, S. C., Yu, L., Bennett, L. & Levine, B., 2021, In: Autophagy. 17, 10, p. 2891-2904 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Tumor-suppressor function of Beclin 1 in breast cancer cells requires E-cadherin

Wijshake, T., Zou, Z., Chen, B., Zhong, L., Xiao, G., Xie, Y., Doench, J. G., Bennett, L. & Levine, B., Feb 2 2021, In: Proceedings of the National Academy of Sciences of the United States of America. 118, 5, e2020478118.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2020

Interaction between the autophagy protein Beclin 1 and Na⁺,K⁺-ATPase during starvation, exercise, and ischemia

Fernández, Á. F., Liu, Y., Ginet, V., Shi, M., Nah, J., Zou, Z., Zhou, A., Posner, B. A., Xiao, G., Tanguy, M., Paradis, V., Sadoshima, J., Rautou, P. E., Puyal, J., Hu, M. C. & Levine, B., Jan 16 2020, In: JCI Insight. 5, 1, e133282.

Research output: Contribution to journal › Article › peer-review

Open Access

36 Scopus citations

Structural basis for polyglutamate chain initiation and elongation by TTLL family enzymes

Mahalingan, K. K., Keith Keenan, E., Strickland, M., Li, Y., Liu, Y., Ball, H. L., Tanner, M. E., Tjandra, N. & Roll-Mecak, A., Sep 1 2020, In: Nature Structural and Molecular Biology. 27, 9, p. 802-813 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

30 Scopus citations

The tripartite interaction of phosphate, autophagy, and αKlotho in health maintenance

Shi, M., Maique, J., Shaffer, J., Davidson, T., Sebti, S., Fernández, Á. F., Zou, Z., Yan, S., Levine, B., Moe, O. W. & Hu, M. C., Feb 1 2020, In: FASEB Journal. 34, 2, p. 3129-3150 22 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

TLR9 and beclin 1 crosstalk regulates muscle AMPK activation in exercise

Liu, Y., Nguyen, P. T., Wang, X., Zhao, Y., Meacham, C. E., Zou, Z., Bordieanu, B., Johanns, M., Vertommen, D., Wijshake, T., May, H., Xiao, G., Shoji-Kawata, S., Rider, M. H., Morrison, S. J., Mishra, P. & Levine, B., Feb 27 2020, In: Nature. 578, 7796, p. 605-609 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Scopus citations

Upregulation of Rubicon promotes autosis during myocardial ischemia/reperfusion injury

Nah, J., Zhai, P., Huang, C. Y., Fernández, Á. F., Mareedu, S., Levine, B. & Sadoshima, J., Jun 1 2020, In: Journal of Clinical Investigation. 130, 6, p. 2978-2991 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

84 Scopus citations

2019

Testis-specific Arf promoter expression in a transposase-aided BAC transgenic mouse model

Sung, C. Y., Liu, Y. T., Bennett, L. B., Devitt, C. C. & Skapek, S. X., Dec 1 2019, In: Molecular Biology Reports. 46, 6, p. 6243-6252 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2018

An increase in LRRK2 suppresses autophagy and enhances dectin-1–induced immunity in a mouse model of colitis

Takagawa, T., Kitani, A., Fuss, I., Levine, B., Brant, S. R., Peter, I., Tajima, M., Nakamura, S. & Strober, W., Jun 6 2018, In: Science translational medicine. 10, 444, eaan8162.

Research output: Contribution to journal › Article › peer-review

Open Access

89 Scopus citations

Beclin-1-Dependent Autophagy Protects the Heart during Sepsis

Sun, Y., Yao, X., Zhang, Q. J., Zhu, M., Liu, Z-P., Ci, B., Xie, Y., Carlson, D. L., Rothermel, B. A., Sun, Y., Levine, B., Hill, J. A., Wolf, S. E., Minei, J. P. & Zang, Q., Nov 13 2018, In: Circulation. 138, 20, p. 2247-2262 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

256 Scopus citations

Cell Penetration Profiling Using the Chloroalkane Penetration Assay

Peraro, L., Deprey, K. L., Moser, M. K., Zou, Z., Ball, H. L., Levine, B. & Kritzer, J. A., Sep 12 2018, In: Journal of the American Chemical Society. 140, 36, p. 11360-11369 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

94 Scopus citations

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

Fernández, Á. F., Sebti, S., Wei, Y., Zou, Z., Shi, M., McMillan, K. L., He, C., Ting, T., Liu, Y., Chiang, W. C., Marciano, D. K., Schiattarella, G. G., Bhagat, G., Moe, O. W., Hu, M. C. & Levine, B., Jun 7 2018, In: Nature. 558, 7708, p. 136-140 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

438 Scopus citations

High-Throughput Screens to Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding

Chiang, W. C., Wei, Y., Kuo, Y. C., Wei, S., Zhou, A., Zou, Z., Yehl, J., Ranaghan, M. J., Skepner, A., Bittker, J. A., Perez, J. R., Posner, B. A. & Levine, B., Aug 17 2018, In: ACS chemical biology. 13, 8, p. 2247-2260 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Scopus citations

Increased autophagy blocks HER2-mediated breast tumorigenesis

Vega-Rubín-De-Celis, S., Zou, Z., Fernández, Á. F., Ci, B., Kim, M., Xiao, G., Xie, Y. & Levine, B., Apr 17 2018, In: Proceedings of the National Academy of Sciences of the United States of America. 115, 16, p. 4176-4181 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

Loss of Paneth Cell Autophagy Causes Acute Susceptibility to Toxoplasma gondii-Mediated Inflammation

Burger, E., Araujo, A., López-Yglesias, A., Rajala, M. W., Geng, L., Levine, B., Hooper, L. V., Burstein, E. & Yarovinsky, F., Feb 14 2018, In: Cell Host and Microbe. 23, 2, p. 177-190.e4

Research output: Contribution to journal › Article › peer-review

Open Access

82 Scopus citations

2017

A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease

Rocchi, A., Yamamoto, S., Ting, T., Fan, Y., Sadleir, K., Wang, Y., Zhang, W., Huang, S., Levine, B., Vassar, R. & He, C., Aug 2017, In: PLoS genetics. 13, 8, e1006962.

Research output: Contribution to journal › Article › peer-review

Open Access

111 Scopus citations

Autophagy wins the 2016 Nobel Prizein Physiology or Medicine: Breakthroughs in baker's yeast fuel advances in biomedical research

Levine, B. & Klionsky, D. J., Jan 10 2017, In: Proceedings of the National Academy of Sciences of the United States of America. 114, 2, p. 201-205 5 p.

Research output: Contribution to journal › Article › peer-review

126 Scopus citations

BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy

Su, M., Li, Y., Wyborny, S., Neau, D., Chakravarthy, S., Levine, B., Colbert, C. L. & Sinha, S. C., May 1 2017, In: Protein Science. 26, 5, p. 972-984 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Scopus citations

Diversity-Oriented Stapling Yields Intrinsically Cell-Penetrant Inducers of Autophagy

Peraro, L., Zou, Z., Makwana, K. M., Cummings, A. E., Ball, H. L., Yu, H., Lin, Y. S., Levine, B. & Kritzer, J. A., Jun 14 2017, In: Journal of the American Chemical Society. 139, 23, p. 7792-7802 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

113 Scopus citations

Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice

Bian, A., Shi, M., Flores, B., Gillings, N., Li, P., Yan, S. X., Levine, B., Xing, C. & Hu, M. C., Sep 2017, In: PloS one. 12, 9, e0181848.

Research output: Contribution to journal › Article › peer-review

Open Access

35 Scopus citations

Emerging functions of the Fanconi anemia pathway at a glance

Sumpter, R. & Levine, B., Aug 15 2017, In: Journal of cell science. 130, 16, p. 2657-2662 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

31 Scopus citations

Leucine reduces reactive oxygen species levels via an energy metabolism switch by activation of the mTOR-HIF-1α pathway in porcine intestinal epithelial cells

Hu, J., Nie, Y., Chen, S., Xie, C., Fan, Q., Wang, Z., Long, B., Yan, G., Zhong, Q. & Yan, X., Aug 2017, In: International Journal of Biochemistry and Cell Biology. 89, p. 42-56 15 p.

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

MTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy

Bartolomeo, R., Cinque, L., De Leonibus, C., Forrester, A., Salzano, A. C., Monfregola, J., De Gennaro, E., Nusco, E., Azario, I., Lanzara, C., Serafini, M., Levine, B., Ballabio, A. & Settembre, C., Oct 2 2017, In: Journal of Clinical Investigation. 127, 10, p. 3717-3729 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

68 Scopus citations

MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy

Ma, X., Zhang, S., He, L., Rong, Y., Brier, L. W., Sun, Q., Liu, R., Fan, W., Chen, S., Yue, Z., Kim, J., Guan, K. L., Li, D. & Zhong, Q., Mar 4 2017, In: Autophagy. 13, 3, p. 592-607 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

73 Scopus citations

Peroxisomal protein PEX13 functions in selective autophagy

Lee, M. Y., Sumpter, R., Zou, Z., Sirasanagandla, S., Wei, Y., Mishra, P., Rosewich, H., Crane, D. I. & Levine, B., Jan 1 2017, In: EMBO Reports. 18, 1, p. 48-60 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

33 Scopus citations

Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor

Wei, Y., Chiang, W. C., Sumpter, R., Mishra, P. & Levine, B., Jan 12 2017, In: Cell. 168, 1-2, p. 224-238.e10

Research output: Contribution to journal › Article › peer-review

Open Access

549 Scopus citations

Structural insights into the interaction of the conserved mammalian proteins GAPR-1 and Beclin 1, a key autophagy protein

Li, Y., Zhao, Y., Su, M., Glover, K., Chakravarthy, S., Colbert, C. L., Levine, B. & Sinha, S. C., Sep 2017, In: Acta Crystallographica Section D: Structural Biology. 73, 9, p. 775-792 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

The Autophagy-Related Beclin-1 Protein Requires the Coiled-Coil and BARA Domains to Form a Homodimer with Submicromolar Affinity

Ranaghan, M. J., Durney, M. A., Mesleh, M. F., McCarren, P. R., Garvie, C. W., Daniels, D. S., Carey, K. L., Skepner, A. P., Levine, B. & Perez, J. R., Dec 26 2017, In: Biochemistry. 56, 51, p. 6639-6651 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

The Ubiquitin Ligase Smurf1 Functions in Selective Autophagy of Mycobacterium tuberculosis and Anti-tuberculous Host Defense

Franco, L. H., Nair, V. R., Scharn, C. R., Xavier, R. J., Torrealba, J. R., Shiloh, M. U. & Levine, B., Jan 11 2017, In: Cell Host and Microbe. 21, 1, p. 59-72 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

146 Scopus citations

2016

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

Park, S., Buck, M. D., Desai, C., Zhang, X., Loginicheva, E., Martinez, J., Freeman, M. L., Saitoh, T., Akira, S., Guan, J. L., He, Y. W., Blackman, M. A., Handley, S. A., Levine, B., Green, D. R., Reese, T. A., Artyomov, M. N. & Virgin, H. W., Jan 13 2016, In: Cell Host and Microbe. 19, 1, p. 91-101 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Pietrocola, F., Pol, J., Vacchelli, E., Rao, S., Enot, D. P., Baracco, E. E., Levesque, S., Castoldi, F., Jacquelot, N., Yamazaki, T., Senovilla, L., Marino, G., Aranda, F., Durand, S., Sica, V., Chery, A., Lachkar, S., Sigl, V., Bloy, N., Buque, A., & 10 othersFalzoni, S., Ryffel, B., Apetoh, L., Di Virgilio, F., Madeo, F., Maiuri, M. C., Zitvogel, L., Levine, B., Penninger, J. M. & Kroemer, G., Jul 11 2016, In: Cancer Cell. 30, 1, p. 147-160 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

382 Scopus citations

Drp1-dependent mitochondrial autophagy plays a protective role against pressure overload-induced mitochondrial dysfunction and heart failure

Shirakabe, A., Zhai, P., Ikeda, Y., Saito, T., Maejima, Y., Hsu, C. P., Nomura, M., Egashira, K., Levine, B. & Sadoshima, J., Mar 29 2016, In: Circulation. 133, 13, p. 1249-1263 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

327 Scopus citations

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis

Dong, X., Cheng, A., Zou, Z., Yang, Y. S., Sumpter, R. M., Huang, C. L., Bhagat, G., Virgin, H. W., Lira, S. A. & Levine, B., Mar 15 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 11, p. 2994-2999 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Fanconi Anemia Proteins Function in Mitophagy and Immunity

Sumpter, R., Sirasanagandla, S., Fernández, Á. F., Wei, Y., Dong, X., Franco, L., Zou, Z., Marchal, C., Lee, M. Y., Clapp, D. W., Hanenberg, H. & Levine, B., May 5 2016, In: Cell. 165, 4, p. 867-881 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

198 Scopus citations

Genetic inhibition of autophagy promotes p53 loss-ofheterozygosity and tumorigenesis

Lee, E., Wei, Y., Zou, Z., Tucker, K., Rakheja, D., Levine, B. & Amatruda, J. F., 2016, In: Oncotarget. 7, 42, p. 67919-67933 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

16 Scopus citations

Microfold Cells Actively Translocate Mycobacterium tuberculosis to Initiate Infection

Nair, V. R., Franco, L. H., Zacharia, V. M., Khan, H. S., Stamm, C. E., You, W., Marciano, D. K., Yagita, H., Levine, B. & Shiloh, M. U., Aug 2 2016, In: Cell Reports. 16, 5, p. 1253-1258 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Scopus citations

Simultaneous inhibition of the ubiquitin-proteasome system and autophagy enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells

Li, X., Zhu, F., Jiang, J., Sun, C., Zhong, Q., Shen, M., Wang, X., Tian, R., Shi, C., Xu, M., Peng, F., Guo, X., Hu, J., Ye, D., Wang, M. & Qin, R., Sep 1 2016, In: Autophagy. 12, 9, p. 1521-1537 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

71 Scopus citations

αklotho mitigates progression of aki to ckd through activation of autophagy

Shi, M., Flores, B., Gillings, N., Bian, A., Cho, H. J., Yan, S. X., Liu, Y., Levine, B., Moe, O. W. & Hu, M. C., 2016, In: Journal of the American Society of Nephrology. 27, 8, p. 2331-2345 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

138 Scopus citations

2015

A noncanonical autophagy pathway restricts toxoplasma gondii growth in a strain-specific manner in IFN-γ-activated human cells

Selleck, E. M., Orchard, R. C., Lassen, K. G., Beatty, W. L., Xavier, R. J., Levine, B., Virgin, H. W. & David Sibley, L., 2015, In: mBio. 6, 5, e01157-15.

Research output: Contribution to journal › Article › peer-review

Open Access

116 Scopus citations

ATG14 controls SNARE-mediated autophagosome fusion with a lysosome

Liu, R., Zhi, X. & Zhong, Q., Jan 1 2015, In: Autophagy. 11, 5, p. 847-849 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

62 Scopus citations

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

Diao, J., Liu, R., Rong, Y., Zhao, M., Zhang, J., Lai, Y., Zhou, Q., Wilz, L. M., Li, J., Vivona, S., Pfuetzner, R. A., Brunger, A. T. & Zhong, Q., Apr 23 2015, In: Nature. 520, 7548, p. 563-566 4 p.

Research output: Contribution to journal › Article › peer-review

430 Scopus citations

Autophagy in cancer

Zhi, X. & Zhong, Q., Feb 3 2015, In: F1000Prime Reports. 7, 18.

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Autophagy in malignant transformation and cancer progression

Galluzzi, L., Pietrocola, F., Bravo-San Pedro, J. M., Amaravadi, R. K., Baehrecke, E. H., Cecconi, F., Codogno, P., Debnath, J., Gewirtz, D. A., Karantza, V., Kimmelman, A., Kumar, S., Levine, B., Maiuri, M. C., Martin, S. J., Penninger, J., Piacentini, M., Rubinsztein, D. C., Simon, H. U., Simonsen, A., & 4 othersThorburn, A. M., Velasco, G., Ryan, K. M. & Kroemer, G., Apr 1 2015, In: EMBO Journal. 34, 7, p. 856-880 25 p.

Research output: Contribution to journal › Article › peer-review

Open Access

969 Scopus citations

BAX and BAK1 are dispensable for ABT-737- induced dissociation of the BCL2-BECN1 complex and autophagy

Pedro, J. M. B. S., Wei, Y., Sica, V., Maiuri, M. C., Zou, Z., Kroemer, G. & Levine, B., Jan 1 2015, In: Autophagy. 11, 3, p. 452-459 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

79 Scopus citations

C-terminal variable AGES domain of Thymosin β4: The molecule's primary contribution in support of post-ischemic cardiac function and repair

Hinkel, R., Ball, H. L., DiMaio, J. M., Shrivastava, S., Thatcher, J. E., Singh, A. N., Sun, X., Faskerti, G., Olson, E. N., Kupatt, C. & Bock-Marquette, I., Oct 1 2015, In: Journal of Molecular and Cellular Cardiology. 87, p. 113-125 13 p.

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

Collins, A. C., Cai, H., Li, T., Franco, L. H., Li, X. D., Nair, V. R., Scharn, C. R., Stamm, C. E., Levine, B., Chen, Z. J. & Shiloh, M. U., Jun 1 2015, In: Cell Host and Microbe. 17, 6, p. 820-828 9 p.

Research output: Contribution to journal › Article › peer-review

277 Scopus citations

Int Med - Autophagy Rsrch Ctr

Research output

Search results