β-Catenin regulates tumor-derived PD-L1

Chuanhui Han; Yang Xin Fu

doi:10.1084/jem.20200684

β-Catenin regulates tumor-derived PD-L1

Chuanhui Han, Yang Xin Fu

Research output: Contribution to journal › Comment/debate › peer-review

11 Scopus citations

Abstract

In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin-dependent manner, and blocking the AKT pathway synergizes with anti-PD-1 in a glioblastoma model.

Original language	English (US)
Journal	The Journal of experimental medicine
Volume	217
Issue number	11
DOIs	https://doi.org/10.1084/jem.20200684
State	Published - Nov 2 2020

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1084/jem.20200684

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@article{274b548c319d4dbebc531a8bf3014949,

title = "β-Catenin regulates tumor-derived PD-L1",

abstract = "In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin-dependent manner, and blocking the AKT pathway synergizes with anti-PD-1 in a glioblastoma model.",

author = "Chuanhui Han and Fu, {Yang Xin}",

note = "Publisher Copyright: {\textcopyright} 2020 Han and Fu.",

year = "2020",

month = nov,

day = "2",

doi = "10.1084/jem.20200684",

language = "English (US)",

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T1 - β-Catenin regulates tumor-derived PD-L1

AU - Han, Chuanhui

AU - Fu, Yang Xin

PY - 2020/11/2

Y1 - 2020/11/2

N2 - In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin-dependent manner, and blocking the AKT pathway synergizes with anti-PD-1 in a glioblastoma model.

AB - In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin-dependent manner, and blocking the AKT pathway synergizes with anti-PD-1 in a glioblastoma model.

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U2 - 10.1084/jem.20200684

DO - 10.1084/jem.20200684

M3 - Comment/debate

C2 - 32860048

AN - SCOPUS:85090174007

SN - 0022-1007

VL - 217

JO - The Journal of experimental medicine

JF - The Journal of experimental medicine

IS - 11

ER -

β-Catenin regulates tumor-derived PD-L1

Abstract

ASJC Scopus subject areas

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