zPoly(D, L-lactide-co-glycolide)/poly(ethylenimine) blend matrix system for pH sensitive drug delivery

Damon Sutton; Remy Durand; Xintao Shuai; Jinming Gao

doi:10.1002/app.22636

zPoly(D, L-lactide-co-glycolide)/poly(ethylenimine) blend matrix system for pH sensitive drug delivery

Damon Sutton, Remy Durand, Xintao Shuai, Jinming Gao

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Poly(D,L-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and found to form a homogeneous pH sensitive matrix for drug release. Differential scanning calorimetry (DSC) studies of the PLGA/PEI blends showed a single glass transition temperature at all compositions. Fourier transform infrared spectroscopy (FTIR) demonstrated that the PLGA carbonyl peak at 1760 cm ^-1 shifted to 1666 cm ^-1 as a result of amide bond formation between the two polymers. This was confirmed by ¹³C nuclear magnetic resonance studies. A PLGA/PEI matrix of 90/10 weight ratio was chosen for evaluation for controlled drug release. Both hydrophobic β-lapachone and hydro philic rhodamine B showed pH dependent release profiles with faster release kinetics at lower pH values. The observed pH sensitive drug release was mainly attributed to two factors, pH dependent swelling and protonation of the PEI-PLGA matrix. These results demonstrate utility of a PLGA/ PEI matrix and its potential application in pH responsive drug delivery.

Original language	English (US)
Pages (from-to)	89-96
Number of pages	8
Journal	Journal of Applied Polymer Science
Volume	100
Issue number	1
DOIs	https://doi.org/10.1002/app.22636
State	Published - Apr 5 2006

Keywords

PH sensitive drug delivery
Poly(D,L-lactide-co-glycolide)
Poly(ethylenimine)
Polymer blends

ASJC Scopus subject areas

General Chemistry
Surfaces, Coatings and Films
Polymers and Plastics
Materials Chemistry

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title = "zPoly(D, L-lactide-co-glycolide)/poly(ethylenimine) blend matrix system for pH sensitive drug delivery",

abstract = "Poly(D,L-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and found to form a homogeneous pH sensitive matrix for drug release. Differential scanning calorimetry (DSC) studies of the PLGA/PEI blends showed a single glass transition temperature at all compositions. Fourier transform infrared spectroscopy (FTIR) demonstrated that the PLGA carbonyl peak at 1760 cm -1 shifted to 1666 cm -1 as a result of amide bond formation between the two polymers. This was confirmed by 13C nuclear magnetic resonance studies. A PLGA/PEI matrix of 90/10 weight ratio was chosen for evaluation for controlled drug release. Both hydrophobic β-lapachone and hydro philic rhodamine B showed pH dependent release profiles with faster release kinetics at lower pH values. The observed pH sensitive drug release was mainly attributed to two factors, pH dependent swelling and protonation of the PEI-PLGA matrix. These results demonstrate utility of a PLGA/ PEI matrix and its potential application in pH responsive drug delivery.",

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author = "Damon Sutton and Remy Durand and Xintao Shuai and Jinming Gao",

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AU - Durand, Remy

AU - Shuai, Xintao

AU - Gao, Jinming

PY - 2006/4/5

Y1 - 2006/4/5

N2 - Poly(D,L-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and found to form a homogeneous pH sensitive matrix for drug release. Differential scanning calorimetry (DSC) studies of the PLGA/PEI blends showed a single glass transition temperature at all compositions. Fourier transform infrared spectroscopy (FTIR) demonstrated that the PLGA carbonyl peak at 1760 cm -1 shifted to 1666 cm -1 as a result of amide bond formation between the two polymers. This was confirmed by 13C nuclear magnetic resonance studies. A PLGA/PEI matrix of 90/10 weight ratio was chosen for evaluation for controlled drug release. Both hydrophobic β-lapachone and hydro philic rhodamine B showed pH dependent release profiles with faster release kinetics at lower pH values. The observed pH sensitive drug release was mainly attributed to two factors, pH dependent swelling and protonation of the PEI-PLGA matrix. These results demonstrate utility of a PLGA/ PEI matrix and its potential application in pH responsive drug delivery.

AB - Poly(D,L-lactide-co-glycolide) (PLGA) and poly(ethylenimine) (PEI) were blended and found to form a homogeneous pH sensitive matrix for drug release. Differential scanning calorimetry (DSC) studies of the PLGA/PEI blends showed a single glass transition temperature at all compositions. Fourier transform infrared spectroscopy (FTIR) demonstrated that the PLGA carbonyl peak at 1760 cm -1 shifted to 1666 cm -1 as a result of amide bond formation between the two polymers. This was confirmed by 13C nuclear magnetic resonance studies. A PLGA/PEI matrix of 90/10 weight ratio was chosen for evaluation for controlled drug release. Both hydrophobic β-lapachone and hydro philic rhodamine B showed pH dependent release profiles with faster release kinetics at lower pH values. The observed pH sensitive drug release was mainly attributed to two factors, pH dependent swelling and protonation of the PEI-PLGA matrix. These results demonstrate utility of a PLGA/ PEI matrix and its potential application in pH responsive drug delivery.

KW - PH sensitive drug delivery

KW - Poly(D,L-lactide-co-glycolide)

KW - Poly(ethylenimine)

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zPoly(D, L-lactide-co-glycolide)/poly(ethylenimine) blend matrix system for pH sensitive drug delivery

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Keywords

ASJC Scopus subject areas

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