YY1 functions with INO80 to activate transcription

Yong Cai; Jingji Jin; Tingting Yao; Aaron J. Gottschalk; Selene K. Swanson; Su Wu; Yang Shi; Michael P. Washburn; Laurence Florens; Ronald C. Conaway; Joan W. Conaway

doi:10.1038/nsmb1276

YY1 functions with INO80 to activate transcription

Yong Cai, Jingji Jin, Tingting Yao, Aaron J. Gottschalk, Selene K. Swanson, Su Wu, Yang Shi, Michael P. Washburn, Laurence Florens, Ronald C. Conaway, Joan W. Conaway

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters.

Original language	English (US)
Pages (from-to)	872-874
Number of pages	3
Journal	Nature Structural and Molecular Biology
Volume	14
Issue number	9
DOIs	https://doi.org/10.1038/nsmb1276
State	Published - Sep 2007
Externally published	Yes

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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@article{e023a6018b5a43af9715c2942ebb515a,

title = "YY1 functions with INO80 to activate transcription",

abstract = "Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters.",

author = "Yong Cai and Jingji Jin and Tingting Yao and Gottschalk, {Aaron J.} and Swanson, {Selene K.} and Su Wu and Yang Shi and Washburn, {Michael P.} and Laurence Florens and Conaway, {Ronald C.} and Conaway, {Joan W.}",

note = "Funding Information: This work was supported in part by US National Institutes of Health grant R37GM41628 (to R.C.C.).",

year = "2007",

month = sep,

doi = "10.1038/nsmb1276",

language = "English (US)",

volume = "14",

pages = "872--874",

journal = "Nature Structural and Molecular Biology",

issn = "1545-9993",

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TY - JOUR

T1 - YY1 functions with INO80 to activate transcription

AU - Cai, Yong

AU - Jin, Jingji

AU - Yao, Tingting

AU - Gottschalk, Aaron J.

AU - Swanson, Selene K.

AU - Wu, Su

AU - Shi, Yang

AU - Washburn, Michael P.

AU - Florens, Laurence

AU - Conaway, Ronald C.

AU - Conaway, Joan W.

N1 - Funding Information: This work was supported in part by US National Institutes of Health grant R37GM41628 (to R.C.C.).

PY - 2007/9

Y1 - 2007/9

N2 - Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters.

AB - Ubiquitously expressed transcription factor Yin-Yang-1 (YY1) controls expression of many genes. YY1 is tightly associated with the human ATP-dependent INO80-like chromatin-remodeling complex (INO80). INO80 is recruited by YY1 to YY1-activated genes, where it functions as an essential coactivator. Binding of YY1 to its DNA sites in target genes requires INO80, suggesting that YY1 uses the INO80 complex not only to activate transcription but also to gain access to target promoters.

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JO - Nature Structural and Molecular Biology

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YY1 functions with INO80 to activate transcription

Abstract

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