Xenotransplantation and Kidney Regenerative Technology

Kazuhiko Yamada; Masayuki Tasaki; Adam Griesemar; Jigesh Shah

doi:10.1016/B978-0-12-801734-0.00084-9

Xenotransplantation and Kidney Regenerative Technology

Kazuhiko Yamada, Masayuki Tasaki, Adam Griesemar, Jigesh Shah

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

The disparity between available donor organs and an increasing recipient waitlist has prompted significant research into alternative avenues to meet this growing demand. Potential options include renal regenerative medicine through the use of various cell-based therapies as well as de-novo organ generation via bioengineered scaffolds. Conversely, xenotransplantation, utilizing pigs as source for potential donor organs, remains a more promising option once specific xenogeneic related immunologic, physiologic, and infectious barriers can be resolved. Reviews of the most recent advances that are available for both renal regeneration as well as renal xenotransplantation are provided in this chapter.

Original language	English (US)
Title of host publication	Kidney Transplantation, Bioengineering, and Regeneration
Subtitle of host publication	Kidney Transplantation in the Regenerative Medicine Era
Publisher	Elsevier Inc.
Pages	1151-1161
Number of pages	11
ISBN (Electronic)	9780128018361
ISBN (Print)	9780128017340
DOIs	https://doi.org/10.1016/B978-0-12-801734-0.00084-9
State	Published - Jul 6 2017
Externally published	Yes

Keywords

Blastocyst complementation
De-novo organ generation
Immunology of xenografts
Metanephros of growing xenoembryos
Transgenic swine donors

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/B978-0-12-801734-0.00084-9

Cite this

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abstract = "The disparity between available donor organs and an increasing recipient waitlist has prompted significant research into alternative avenues to meet this growing demand. Potential options include renal regenerative medicine through the use of various cell-based therapies as well as de-novo organ generation via bioengineered scaffolds. Conversely, xenotransplantation, utilizing pigs as source for potential donor organs, remains a more promising option once specific xenogeneic related immunologic, physiologic, and infectious barriers can be resolved. Reviews of the most recent advances that are available for both renal regeneration as well as renal xenotransplantation are provided in this chapter.",

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AU - Yamada, Kazuhiko

AU - Tasaki, Masayuki

AU - Griesemar, Adam

AU - Shah, Jigesh

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AB - The disparity between available donor organs and an increasing recipient waitlist has prompted significant research into alternative avenues to meet this growing demand. Potential options include renal regenerative medicine through the use of various cell-based therapies as well as de-novo organ generation via bioengineered scaffolds. Conversely, xenotransplantation, utilizing pigs as source for potential donor organs, remains a more promising option once specific xenogeneic related immunologic, physiologic, and infectious barriers can be resolved. Reviews of the most recent advances that are available for both renal regeneration as well as renal xenotransplantation are provided in this chapter.

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KW - Immunology of xenografts

KW - Metanephros of growing xenoembryos

KW - Transgenic swine donors

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ER -

Xenotransplantation and Kidney Regenerative Technology

Abstract

Keywords

ASJC Scopus subject areas

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