Xenobiotic metabolism in the fourth dimension: PARtners in time

Research output: Contribution to journalShort surveypeer-review

10 Scopus citations


A significant portion of the transcriptome in mammals, including the PAR bZIP transcription factors DBP, HLF, and TEF, is under circadian clock control. In this issue of Cell Metabolism, Gachon and colleagues (Gachon et al., 2006) show that disruption of these three genes in mice alters gene expression patterns of many proteins involved in drug metabolism and in liver and kidney responses to xenobiotic agents. Triple mutant mice have severe physiological deficits, including increased hypersensitivity to xenobiotic agents and premature aging, highlighting the profound effect the circadian clock has on this important response system.

Original languageEnglish (US)
Pages (from-to)3-4
Number of pages2
JournalCell Metabolism
Issue number1
StatePublished - Jul 2006

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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