Wortmannin and LY294002 inhibit the insulin-induced down-regulation of IRS-1 in 3T3-L1 adipocytes

Medicine & Life Sciences

• 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 64%
• 3T3-L1 Cells 66%
• Adipocytes 51%
• Aminoglycosides 7%
• Anti-Bacterial Agents 4%
• Calcium 9%
• Down-Regulation 38%
• In Vitro Techniques 8%
• Insulin 37%
• Insulin Receptor Substrate Proteins 70%
• Neomycin 8%
• phosphatidylinositol 3,4,5-triphosphate 9%
• Phosphatidylinositol 3-Kinase 20%
• Phosphatidylinositols 14%
• Phosphorylation 4%
• Tyrosine 6%
• Wortmannin 67%

Chemical Compounds

• Aminoglycoside Antibiotic Agent 6%
• Insulin Derivative 55%
• LY294002 100%
• Neomycin 6%
• Phosphatidylinositol 21%
• Phosphoinositide 6%
• Tyrosine 4%
• Wortmannin 93%