Abstract
Adhesion and migration of T cells are controlled by chemokines and by adhesion molecules, especially integrins, and have critical roles in the normal physiological function of T lymphocytes. Using an RNA-mediated interference screen, we identified the WNK1 kinase as a regulator of both integrin-mediated adhesion and T cell migration. We found that WNK1 is a negative regulator of integrin-mediated adhesion, whereas it acts as a positive regulator of migration via the kinases OXSR1 and STK39 and the ion co-transporter SLC12A2. WNK1-deficient T cells home less efficiently to lymphoid organs and migrate more slowly through them. Our results reveal that a pathway previously known only to regulate salt homeostasis in the kidney functions to balance T cell adhesion and migration.
Original language | English (US) |
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Pages (from-to) | 1075-1083 |
Number of pages | 9 |
Journal | Nature immunology |
Volume | 17 |
Issue number | 9 |
DOIs | |
State | Published - Aug 19 2016 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology