White paper on pancreatic ductal adenocarcinoma from society of abdominal radiology’s disease-focused panel for pancreatic ductal adenocarcinoma: Part II, update on imaging techniques and screening of pancreatic cancer in high-risk individuals

Naveen M. Kulkarni, Lorenzo Mannelli, Marc Zins, Priya R. Bhosale, Hina Arif-Tiwari, Olga R. Brook, Elizabeth M. Hecht, Fay Kastrinos, Zhen Jane Wang, Erik V. Soloff, Parag P. Tolat, Guillermo Sangster, Jason Fleming, Eric P. Tamm, Avinash R. Kambadakone

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive gastrointestinal malignancy with a poor 5-year survival rate. Its high mortality rate is attributed to its aggressive biology and frequently late presentation. While surgical resection remains the only potentially curative treatment, only 10–20% of patients will present with surgically resectable disease. Over the past several years, development of vascular bypass graft techniques and introduction of neoadjuvant treatment regimens have increased the number of patients who can undergo resection with a curative intent. While the role of conventional imaging in the detection, characterization, and staging of patients with PDAC is well established, its role in monitoring treatment response, particularly following neoadjuvant therapy remains challenging because of the complex anatomic and histological nature of PDAC. Novel morphologic and functional imaging techniques (such as DECT, DW-MRI, and PET/MRI) are being investigated to improve the diagnostic accuracy and the ability to measure response to therapy. There is also a growing interest to detect PDAC and its precursor lesions at an early stage in asymptomatic patients to increase the likelihood of achieving cure. This has led to the development of pancreatic cancer screening programs. This article will review recent updates in imaging techniques and the current status of screening and surveillance of individuals at a high risk of developing PDAC.

Original languageEnglish (US)
Pages (from-to)729-742
Number of pages14
JournalAbdominal Radiology
Volume45
Issue number3
DOIs
StatePublished - Mar 1 2020
Externally publishedYes

Keywords

  • DECT
  • DW-MRI
  • Pancreatic cancer screening
  • Pancreatic ductal adenocarcinoma
  • PET/MR

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Gastroenterology
  • Urology

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