Weaving βKlotho into bile acid metabolism

Antonio Moschetta, Steven A. Kliewer

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Bile acids are natural detergents that assist in the absorption and digestion of fats in the intestine. In liver, the synthesis of bile acids from cholesterol is regulated by multiple signaling cascades that repress transcription of the gene encoding cholesterol 7α-hydroxylase (CYP7A1), the rate-limiting enzyme in the classic bile acid synthesis pathway. In this issue of the JCI, Ito and coworkers demonstrate that mice lacking βKlotho, a membrane protein with 2 putative glycosidase domains, have increased Cyp7a1 mRNA levels and bile acid concentrations (see the related article beginning on page 2202). βKlotho-KO mice also have small gallbladders and are resistant to cholesterol gallstone formation. These findings highlight the central role of βKlotho in bile acid homeostasis and raise the possibility that this protein could be a pharmacologic target for the treatment of gallstones.

Original languageEnglish (US)
Pages (from-to)2075-2077
Number of pages3
JournalJournal of Clinical Investigation
Issue number8
StatePublished - Aug 2005

ASJC Scopus subject areas

  • General Medicine


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