Vitamin D status is not related to development of atrial fibrillation in the community

Michiel Rienstra, Susan Cheng, Martin G. Larson, Elizabeth L. McCabe, Sarah L. Booth, Paul F. Jacques, Steven A. Lubitz, Xiaoyan Yin, Daniel Levy, Jared W. Magnani, Patrick T. Ellinor, Emelia J. Benjamin, Thomas J. Wang

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Background: Atrial fibrillation (AF) is common and is an important cause of cardiovascular morbidity and mortality. Vitamin D is an emerging risk factor in cardiovascular disease, and vitamin D status is modifiable. Thus, we sought to investigate whether vitamin D status predisposed to the development of AF in a community-based sample. Methods: We evaluated the relation between vitamin D status and development of AF in 2,930 participants of the Framingham Heart Study, Massachusetts, USA, without prevalent AF. The mean age was 65 ± 11 years, and 56% were women. Vitamin D status was assessed by measuring 25-hydroxyvitamin D (25[OH]D) concentrations. Multivariable Cox regression models were adjusted for AF risk factors and season. Results: During a mean follow-up of 9.9 years, 425 participants (15%) developed AF. In Cox proportional hazards models, 25(OH)D was not associated with development of AF, with a multivariable-adjusted hazard ratio of 0.99 per SD increment in 25(OH)D levels (95% CI 0.88-1.10, P =.81). Also, no relation was found in models including 25(OH)D as a dichotomous variable (above and below the cohort-specific 20th percentile; P =.59). Conclusion: In our community-based sample, vitamin D status was not related to incident AF. Our data suggest that vitamin D deficiency does not promote the development of AF in the ambulatory setting.

Original languageEnglish (US)
Pages (from-to)538-541
Number of pages4
JournalAmerican heart journal
Issue number3
StatePublished - Sep 2011
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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