TY - JOUR
T1 - Vitamin D status is not related to development of atrial fibrillation in the community
AU - Rienstra, Michiel
AU - Cheng, Susan
AU - Larson, Martin G.
AU - McCabe, Elizabeth L.
AU - Booth, Sarah L.
AU - Jacques, Paul F.
AU - Lubitz, Steven A.
AU - Yin, Xiaoyan
AU - Levy, Daniel
AU - Magnani, Jared W.
AU - Ellinor, Patrick T.
AU - Benjamin, Emelia J.
AU - Wang, Thomas J.
N1 - Funding Information:
Sources of funding: This work was supported by grants from the National Institutes of Health ( NO1-HC-25195, K23-HL-074077, R01-AG14759, K23-RR-017376-04, and K24-HL-04334; 1R01HL092577; 1RC1HL101056; 1R01HL102214; 6R01-NS 17950; 1R01HL092577; R01AG028321; 5R21DA027021; 5RO1HL104156; 1K24HL105780 ), the US Department of Agriculture (agreement 58-1950-4-401 ), and the American Heart Association. Dr Rienstra is supported by a grant from the Netherlands Organization for Scientific Research (Rubicon Grant 825.09.020 ). Dr Cheng is supported by a grant from the Ellison Foundation. Dr Magnani is supported by American Heart Association Award 09FTF2190028 . This work was partially supported by the Evans Center for Interdisciplinary Biomedical Research ARC on Atrial Fibrillation Initiative at Boston University.
Funding Information:
The Framingham Heart Study is supported by the National Heart, Lung and Blood Institute (contract NO1-HC-25195).
PY - 2011/9
Y1 - 2011/9
N2 - Background: Atrial fibrillation (AF) is common and is an important cause of cardiovascular morbidity and mortality. Vitamin D is an emerging risk factor in cardiovascular disease, and vitamin D status is modifiable. Thus, we sought to investigate whether vitamin D status predisposed to the development of AF in a community-based sample. Methods: We evaluated the relation between vitamin D status and development of AF in 2,930 participants of the Framingham Heart Study, Massachusetts, USA, without prevalent AF. The mean age was 65 ± 11 years, and 56% were women. Vitamin D status was assessed by measuring 25-hydroxyvitamin D (25[OH]D) concentrations. Multivariable Cox regression models were adjusted for AF risk factors and season. Results: During a mean follow-up of 9.9 years, 425 participants (15%) developed AF. In Cox proportional hazards models, 25(OH)D was not associated with development of AF, with a multivariable-adjusted hazard ratio of 0.99 per SD increment in 25(OH)D levels (95% CI 0.88-1.10, P =.81). Also, no relation was found in models including 25(OH)D as a dichotomous variable (above and below the cohort-specific 20th percentile; P =.59). Conclusion: In our community-based sample, vitamin D status was not related to incident AF. Our data suggest that vitamin D deficiency does not promote the development of AF in the ambulatory setting.
AB - Background: Atrial fibrillation (AF) is common and is an important cause of cardiovascular morbidity and mortality. Vitamin D is an emerging risk factor in cardiovascular disease, and vitamin D status is modifiable. Thus, we sought to investigate whether vitamin D status predisposed to the development of AF in a community-based sample. Methods: We evaluated the relation between vitamin D status and development of AF in 2,930 participants of the Framingham Heart Study, Massachusetts, USA, without prevalent AF. The mean age was 65 ± 11 years, and 56% were women. Vitamin D status was assessed by measuring 25-hydroxyvitamin D (25[OH]D) concentrations. Multivariable Cox regression models were adjusted for AF risk factors and season. Results: During a mean follow-up of 9.9 years, 425 participants (15%) developed AF. In Cox proportional hazards models, 25(OH)D was not associated with development of AF, with a multivariable-adjusted hazard ratio of 0.99 per SD increment in 25(OH)D levels (95% CI 0.88-1.10, P =.81). Also, no relation was found in models including 25(OH)D as a dichotomous variable (above and below the cohort-specific 20th percentile; P =.59). Conclusion: In our community-based sample, vitamin D status was not related to incident AF. Our data suggest that vitamin D deficiency does not promote the development of AF in the ambulatory setting.
UR - http://www.scopus.com/inward/record.url?scp=80052289025&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052289025&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2011.06.013
DO - 10.1016/j.ahj.2011.06.013
M3 - Article
C2 - 21884873
AN - SCOPUS:80052289025
SN - 0002-8703
VL - 162
SP - 538
EP - 541
JO - American heart journal
JF - American heart journal
IS - 3
ER -