TY - JOUR
T1 - Vitamin D and Heart Failure
AU - Marshall Brinkley, D.
AU - Ali, Omair M.
AU - Zalawadiya, Sandip K.
AU - Wang, Thomas J.
N1 - Funding Information:
Conflict of Interest D. Marshall Brinkley, Omair M. Ali, and Sandip K. Zalawadiya declare no conflicts of interest. Thomas J Wang reports prior research support from Diasorin, Inc. for a research study.
Publisher Copyright:
© 2017, Springer Science+Business Media, LLC.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - Purpose: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure. Recent Findings.: Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality. However, trials assessing the influence of vitamin D supplementation on surrogate markers and clinical outcomes in heart failure have generally been small and inconclusive. Summary: There are insufficient data to recommend routine assessment or supplementation of vitamin D for the prevention or treatment of chronic heart failure. Prospective trials powered for clinical outcomes are warranted.
AB - Purpose: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure. Recent Findings.: Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality. However, trials assessing the influence of vitamin D supplementation on surrogate markers and clinical outcomes in heart failure have generally been small and inconclusive. Summary: There are insufficient data to recommend routine assessment or supplementation of vitamin D for the prevention or treatment of chronic heart failure. Prospective trials powered for clinical outcomes are warranted.
KW - Cardiovascular disease
KW - Heart failure
KW - Outcomes
KW - Vitamin D
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U2 - 10.1007/s11897-017-0355-7
DO - 10.1007/s11897-017-0355-7
M3 - Review article
C2 - 28808858
AN - SCOPUS:85028547741
SN - 1546-9530
VL - 14
SP - 410
EP - 420
JO - Current Heart Failure Reports
JF - Current Heart Failure Reports
IS - 5
ER -