Abstract
Purpose: Vitamin D is principally known for its role in calcium homeostasis, but preclinical studies implicate multiple pathways through which vitamin D may affect cardiovascular function and influence risk for heart failure. Many adults with cardiovascular disease have low vitamin D status, making it a potential therapeutic target. We review the rationale and potential role of vitamin D supplementation in the prevention and treatment of chronic heart failure. Recent Findings.: Substantial observational evidence has associated low vitamin D status with the risk of heart failure, ventricular remodeling, and clinical outcomes in heart failure, including mortality. However, trials assessing the influence of vitamin D supplementation on surrogate markers and clinical outcomes in heart failure have generally been small and inconclusive. Summary: There are insufficient data to recommend routine assessment or supplementation of vitamin D for the prevention or treatment of chronic heart failure. Prospective trials powered for clinical outcomes are warranted.
Original language | English (US) |
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Pages (from-to) | 410-420 |
Number of pages | 11 |
Journal | Current heart failure reports |
Volume | 14 |
Issue number | 5 |
DOIs | |
State | Published - Oct 1 2017 |
Externally published | Yes |
Keywords
- Cardiovascular disease
- Heart failure
- Outcomes
- Vitamin D
ASJC Scopus subject areas
- Emergency Medicine
- Cardiology and Cardiovascular Medicine
- Physiology (medical)