Visualizing the Histone Code on LSD1

Matthew J. Gamble; W. Lee Kraus

doi:10.1016/j.cell.2007.01.017

Visualizing the Histone Code on LSD1

Matthew J. Gamble, W. Lee Kraus

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which appear to be used for this purpose by a number of signal-regulated transcriptional activators.

Original language	English (US)
Pages (from-to)	433-434
Number of pages	2
Journal	Cell
Volume	128
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2007.01.017
State	Published - Feb 9 2007

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2007.01.017

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title = "Visualizing the Histone Code on LSD1",

abstract = "In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which appear to be used for this purpose by a number of signal-regulated transcriptional activators.",

author = "Gamble, {Matthew J.} and Kraus, {W. Lee}",

year = "2007",

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T1 - Visualizing the Histone Code on LSD1

AU - Gamble, Matthew J.

AU - Kraus, W. Lee

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Y1 - 2007/2/9

N2 - In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which appear to be used for this purpose by a number of signal-regulated transcriptional activators.

AB - In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which appear to be used for this purpose by a number of signal-regulated transcriptional activators.

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DO - 10.1016/j.cell.2007.01.017

M3 - Short survey

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SN - 0092-8674

VL - 128

SP - 433

EP - 434

JO - Cell

JF - Cell

IS - 3

ER -

Visualizing the Histone Code on LSD1

Abstract

ASJC Scopus subject areas

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