In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which appear to be used for this purpose by a number of signal-regulated transcriptional activators.
|Original language||English (US)|
|Number of pages||2|
|State||Published - Feb 9 2007|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)