TY - JOUR
T1 - Visual outcome and poor prognostic factors in isolated idiopathic retinal vasculitis
AU - Maleki, Arash
AU - Cao, Jennifer H.
AU - Silpa-Archa, Sukhum
AU - Foster, C. Stephen
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Purpose: To describe the clinical course, visual outcome, and prognosis of isolated, idiopathic retinal vasculitis. Methods: Eighty patients (150 eyes) with isolated, idiopathic retinal vasculitis were included. Demographic data, clinical data, complications at the initial visit and during follow-up, fluorescein angiography, and optical coherence tomography findings were collected from the Massachusetts Eye Research and Surgery Institution (MERSI) database from September 2005 to February 2015. Results: Seventy-five (93.7%) patients required treatment with immunomodulatory therapy. Of those 75 patients, 60 (75%) patients were able to achieve durable remission. Factors which were independently significant predictive of poor visual outcome were lower initial visual acuity (OR: 3.78; 95% CI: 1.75-8.16; P 0.001), cystoid macular edema (OR: 5.54; 95% CI: 1.81-16.99; P 0.003), and macular ischemia (OR: 5.12; 95% CI: 1.12-23.04; P 0.036). Conclusion: The majority (67.25%) of our patients enjoyed a good visual outcome (most recent visit best-corrected visual acuity equal to or better than 20/40 and within one line or better from the baseline) with immunomodulatory therapy. We found that cystoid macular edema, macular ischemia, and lower best-corrected visual acuity during the first consultation visit were significant independent risk factors for poor visual outcome.
AB - Purpose: To describe the clinical course, visual outcome, and prognosis of isolated, idiopathic retinal vasculitis. Methods: Eighty patients (150 eyes) with isolated, idiopathic retinal vasculitis were included. Demographic data, clinical data, complications at the initial visit and during follow-up, fluorescein angiography, and optical coherence tomography findings were collected from the Massachusetts Eye Research and Surgery Institution (MERSI) database from September 2005 to February 2015. Results: Seventy-five (93.7%) patients required treatment with immunomodulatory therapy. Of those 75 patients, 60 (75%) patients were able to achieve durable remission. Factors which were independently significant predictive of poor visual outcome were lower initial visual acuity (OR: 3.78; 95% CI: 1.75-8.16; P 0.001), cystoid macular edema (OR: 5.54; 95% CI: 1.81-16.99; P 0.003), and macular ischemia (OR: 5.12; 95% CI: 1.12-23.04; P 0.036). Conclusion: The majority (67.25%) of our patients enjoyed a good visual outcome (most recent visit best-corrected visual acuity equal to or better than 20/40 and within one line or better from the baseline) with immunomodulatory therapy. We found that cystoid macular edema, macular ischemia, and lower best-corrected visual acuity during the first consultation visit were significant independent risk factors for poor visual outcome.
KW - fluorescein angiography
KW - immunomodulatory therapy
KW - retinal vasculitis
KW - uveitis
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U2 - 10.1097/IAE.0000000000001019
DO - 10.1097/IAE.0000000000001019
M3 - Article
C2 - 26991648
AN - SCOPUS:84961233795
SN - 0275-004X
VL - 36
SP - 1979
EP - 1985
JO - Retina
JF - Retina
IS - 10
ER -