TY - JOUR
T1 - Virus-derived anti-inflammatory proteins
T2 - Potential therapeutics for cancer
AU - Zheng, Donghang
AU - Chen, Hao
AU - Bartee, Mee Y.
AU - Williams, Jennifer
AU - Davids, Jennifer A.
AU - Huang, Emina
AU - Moreb, Jan
AU - Lucas, Alexandra
PY - 2012/6
Y1 - 2012/6
N2 - Inflammatory responses now have a defined central role in cancer cell growth, invasion, and metastases. Anti-inflammatory proteins from viruses target key stages in immune response pathways and have potential as novel therapeutics for cancer, including highly potent virus-derived inhibitors of protease, chemokine, cytokine, and apoptotic cascades that have been identified. Serine proteases, in addition to their conventional roles in thrombosis, thrombolysis, and apoptotic pathways, are essential regulators of inflammation and are associated with developing cancers. Chemokines drive other inflammatory response pathways with central roles in cell invasion and activation as well as establishing the microenvironment of tumors, modulating immune cell infiltration, cancer cell proliferation, metastasis, and angiogenesis. This review focuses on the mechanisms of action and potential for application of viral immunomodulatory proteins as anticancer therapeutics.
AB - Inflammatory responses now have a defined central role in cancer cell growth, invasion, and metastases. Anti-inflammatory proteins from viruses target key stages in immune response pathways and have potential as novel therapeutics for cancer, including highly potent virus-derived inhibitors of protease, chemokine, cytokine, and apoptotic cascades that have been identified. Serine proteases, in addition to their conventional roles in thrombosis, thrombolysis, and apoptotic pathways, are essential regulators of inflammation and are associated with developing cancers. Chemokines drive other inflammatory response pathways with central roles in cell invasion and activation as well as establishing the microenvironment of tumors, modulating immune cell infiltration, cancer cell proliferation, metastasis, and angiogenesis. This review focuses on the mechanisms of action and potential for application of viral immunomodulatory proteins as anticancer therapeutics.
KW - Cancer therapy
KW - Chemokine-binding proteins
KW - Inflammation
KW - M-T1
KW - M-T7
KW - Serp-1
KW - Viral serpins
UR - http://www.scopus.com/inward/record.url?scp=84861850964&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861850964&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2012.03.006
DO - 10.1016/j.molmed.2012.03.006
M3 - Review article
C2 - 22554906
AN - SCOPUS:84861850964
SN - 1471-4914
VL - 18
SP - 304
EP - 310
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 6
ER -