TY - JOUR
T1 - Viral coinfection is associated with improved outcomes in emergency department patients with SARS-CoV-2
AU - RECOVER
AU - Goldberg, Elizabeth M.
AU - Hasegawa, Kohei
AU - Lawrence, Alexis
AU - Kline, Jeffrey A.
AU - Camargo, Carlos A.
AU - Aufderheide, Tom
AU - Beiser, David
AU - Bennett, Chris
AU - Bledsoe, Joseph
AU - Caputo, Nicholas
AU - Carpenter, Christopher
AU - Chang, Anna Marie
AU - Chisolm-Straker, Makini
AU - Courtney, D. Mark
AU - Mycyk, Mark
AU - Del Rios, Marina
AU - Delgado, M. Kit
AU - Peter, John
AU - D'Etienne, James
AU - Dezman, Zach
AU - Guirgis, Faheem
AU - Headden, Gary
AU - House, Hans
AU - Huebinger, Ryan
AU - Jang, Timothy
AU - Kabrhel, Christopher
AU - Lim, Stephen
AU - Limkakeng, Alexander
AU - Madsen, Troy
AU - McCarthy, Danielle
AU - Meltzer, Andrew
AU - Moore, Steven
AU - Newgard, Craig
AU - Nordenholz, Kristen
AU - Pagenhardt, Justine
AU - Platts-Mills, Timothy
AU - Pulia, Michael
AU - Puskarich, Mike
AU - Southerland, Lauren
AU - Sparks, Scott
AU - Swoboda, Henry
AU - Taylor, Lindsay
AU - Tomaszewski, Christian
AU - Turner-Lawrence, Danielle
AU - Vrablik, Marie
AU - Weekes, Anthony
AU - Westafer, Lauren
AU - Whittle, Jessica
AU - Wilburn, John
N1 - Publisher Copyright:
© 2021 by the author(s). This work is made available under the terms of a Creative Commons Attribution License, available at https://creativecommons.org/licenses/by/4.0/
PY - 2021/11
Y1 - 2021/11
N2 - Introduction: Coinfection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and another virus may influence the clinical trajectory of emergency department (ED) patients. However, little empirical data exists on the clinical outcomes of coinfection with SARS-CoV-2 Methods: In this retrospective cohort analysis, we included adults presenting to the ED with confirmed, symptomatic coronavirus 2019 who also underwent testing for additional viral pathogens within 24 hours. To investigate the association between coinfection status with each of the outcomes, we performed logistic regression. Results: Of 6,913 ED patients, 5.7% had coinfection. Coinfected individuals were less likely to experience index visit or 30-day hospitalization (odds ratio [OR] 0.57; 95% confidence interval [CI], 0.36-0.90 and OR 0.39; 95% CI, 0.25-0.62, respectively). Conclusion: Coinfection is relatively uncommon in symptomatic ED patients with SARS-CoV-2 and the clinical short- and long-term outcomes are more favorable in coinfected individuals.
AB - Introduction: Coinfection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) and another virus may influence the clinical trajectory of emergency department (ED) patients. However, little empirical data exists on the clinical outcomes of coinfection with SARS-CoV-2 Methods: In this retrospective cohort analysis, we included adults presenting to the ED with confirmed, symptomatic coronavirus 2019 who also underwent testing for additional viral pathogens within 24 hours. To investigate the association between coinfection status with each of the outcomes, we performed logistic regression. Results: Of 6,913 ED patients, 5.7% had coinfection. Coinfected individuals were less likely to experience index visit or 30-day hospitalization (odds ratio [OR] 0.57; 95% confidence interval [CI], 0.36-0.90 and OR 0.39; 95% CI, 0.25-0.62, respectively). Conclusion: Coinfection is relatively uncommon in symptomatic ED patients with SARS-CoV-2 and the clinical short- and long-term outcomes are more favorable in coinfected individuals.
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U2 - 10.5811/WESTJEM.2021.8.53590
DO - 10.5811/WESTJEM.2021.8.53590
M3 - Article
C2 - 34787549
AN - SCOPUS:85120489330
SN - 1936-900X
VL - 22
SP - 1262
EP - 1269
JO - Western Journal of Emergency Medicine
JF - Western Journal of Emergency Medicine
IS - 6
ER -