TY - JOUR
T1 - Vincristine-induced vocal cord paresis and paralysis in children
AU - Zavala, Hanan
AU - Roby, Brianne Barnett
AU - Day, Andrew
AU - Bostrom, Bruce
AU - Sidman, James
AU - Chinnadurai, Sivakumar
PY - 2019/8
Y1 - 2019/8
N2 - Objectives: To describe three new cases of vincristine-induced vocal cord paresis or paralysis (VIVCPP)in children and to review the diagnosis and management of this neuropathy. Methods: Retrospective case series. Diagnosis of VIVCPP was confirmed by laryngoscopy in all children. Results: Less than 20 cases of VIVCPP in children have been previously documented in the literature. Of the three children in our case series, one had unilateral vincristine-induced vocal cord paresis and two had bilateral VIVCPP. The first two patients each had two separate episodes of paresis, lasting 4 months and 1 month respectively. In the last patient, whose medical course was complicated by many additional factors, vocal cord paralysis persisted for over three years. Conclusions: Clinicians must evaluate children with suspected VIVCPP for concomitant symptoms and signs of vincristine neuropathies and examine the vocal cords via laryngoscopy. The effects of vincristine neurotoxicity can be waxing and waning, demonstrate delayed onset and persist well beyond drug cessation. Further studies are needed to identify effective neuroprotectants and delineate appropriate vincristine dosing in patients with vincristine neurotoxicity and cancer.
AB - Objectives: To describe three new cases of vincristine-induced vocal cord paresis or paralysis (VIVCPP)in children and to review the diagnosis and management of this neuropathy. Methods: Retrospective case series. Diagnosis of VIVCPP was confirmed by laryngoscopy in all children. Results: Less than 20 cases of VIVCPP in children have been previously documented in the literature. Of the three children in our case series, one had unilateral vincristine-induced vocal cord paresis and two had bilateral VIVCPP. The first two patients each had two separate episodes of paresis, lasting 4 months and 1 month respectively. In the last patient, whose medical course was complicated by many additional factors, vocal cord paralysis persisted for over three years. Conclusions: Clinicians must evaluate children with suspected VIVCPP for concomitant symptoms and signs of vincristine neuropathies and examine the vocal cords via laryngoscopy. The effects of vincristine neurotoxicity can be waxing and waning, demonstrate delayed onset and persist well beyond drug cessation. Further studies are needed to identify effective neuroprotectants and delineate appropriate vincristine dosing in patients with vincristine neurotoxicity and cancer.
KW - Chemotherapy
KW - Neuropathy
KW - Neurotoxicity
KW - Vincristine
KW - Vocal cord paralysis
KW - Vocal cord paresis
UR - http://www.scopus.com/inward/record.url?scp=85064743249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064743249&partnerID=8YFLogxK
U2 - 10.1016/j.ijporl.2019.04.001
DO - 10.1016/j.ijporl.2019.04.001
M3 - Article
C2 - 31048222
AN - SCOPUS:85064743249
SN - 0165-5876
VL - 123
SP - 1
EP - 4
JO - International Journal of Pediatric Otorhinolaryngology
JF - International Journal of Pediatric Otorhinolaryngology
ER -