Abstract
Objective: To compare the tidal volume, minute ventilation, and gas exchange caused by mechanical chest compression with and without mechanical ventilatory support during cardiopulmonary resuscitation (CPR) in a laboratory model of cardiac arrest. Design: A laboratory swine model of CPR was used. Eight animals with and eight animals without mechanical ventilation received chest compression (100/min) for 10 min. Coronary perfusion pressure, tidal volume, and minute ventilation were recorded continuously. Interventions: Ventricular fibrillation for 6 min without CPR, then mechanical chest compression for 10 min. Results: During the first minute of chest compression, mean (± S.D.) minute ventilation was 11.2 ± 5.91 l/min in the mechanically ventilated group and 4.5 ± 2.8 l/min in the group without mechanical ventilation (P = 0.01). Minute ventilation gradually declined to 5.8 ± 1.4 1/min and 1.7 ± 1.6 1/min, respectively, during the last minute of chest compression (P < 0.0001). After 10 min of chest compression, mean arterial pH was significantly more acidemic in the group without mechanical ventilation (7.16 ± 0.13 compared with 7.30 ± 0.07 units) and Pco2 was higher (62 ± 19 compared with 35 ± 9 mmHg). Mixed venous Pco2 was also higher (76 ± 15 compared with 61 ± 8 mmHg). Conclusion: Standard chest compression alone produced measurable tidal volume and minute ventilation. However, after 10 min of chest compression following 6 min of untreated ventricular fibrillation, it failed to sustain pulmonary gas exchange as indicated by significantly greater arterial and mixed venous hypercarbic acidosis when compared with a group receiving mechanical ventilation.
Original language | English (US) |
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Pages (from-to) | 143-150 |
Number of pages | 8 |
Journal | Resuscitation |
Volume | 28 |
Issue number | 2 |
DOIs | |
State | Published - Oct 1994 |
Keywords
- Acid-base equilibrium
- Cardiopulmonary resuscitation
- Hypercarbia
- Hypoxia
- Ventilation
ASJC Scopus subject areas
- Emergency Medicine
- Emergency
- Cardiology and Cardiovascular Medicine