Vasoactive intestinal polypeptide: Release into hypophyseal portal blood

Sami I. Said; John C. Porter

doi:10.1016/0024-3205(79)90223-6

Vasoactive intestinal polypeptide: Release into hypophyseal portal blood

Sami I. Said, John C. Porter

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Immunoreactive vasoactive intestinal polypeptide (VIP) was present in portal hypophyseal blood of 24 male rats in concentrations (mean, 995 pg per ml) that were approximately 19 times as high as those in systemic arterial blood (mean, 52 pg per ml). The results demonstrate release of VIP from the hypothalamic-neurohypophyseal complex into the portal circulation, and establish a mechanism for direct influence of the peptide on pituitary function.

Original language	English (US)
Pages (from-to)	227-230
Number of pages	4
Journal	Life Sciences
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/0024-3205(79)90223-6
State	Published - Jan 15 1979

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(79)90223-6

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title = "Vasoactive intestinal polypeptide: Release into hypophyseal portal blood",

abstract = "Immunoreactive vasoactive intestinal polypeptide (VIP) was present in portal hypophyseal blood of 24 male rats in concentrations (mean, 995 pg per ml) that were approximately 19 times as high as those in systemic arterial blood (mean, 52 pg per ml). The results demonstrate release of VIP from the hypothalamic-neurohypophyseal complex into the portal circulation, and establish a mechanism for direct influence of the peptide on pituitary function.",

author = "Said, {Sami I.} and Porter, {John C.}",

note = "Funding Information: We thank Dr . Berta Scharrer for advice and criticism, Renon Mi cal for assistance in the collection of hypophyseal portal blood, and Shirley M. Harvey and Wallace T. Ford, Jr., for help with the radioimmunoassay. Supported by the Medical Research Service of the Veterans Administration, and by grants from the National Institutes of Health, U .S . Public Health Service .",

year = "1979",

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doi = "10.1016/0024-3205(79)90223-6",

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TY - JOUR

T1 - Vasoactive intestinal polypeptide

T2 - Release into hypophyseal portal blood

AU - Said, Sami I.

AU - Porter, John C.

N1 - Funding Information: We thank Dr . Berta Scharrer for advice and criticism, Renon Mi cal for assistance in the collection of hypophyseal portal blood, and Shirley M. Harvey and Wallace T. Ford, Jr., for help with the radioimmunoassay. Supported by the Medical Research Service of the Veterans Administration, and by grants from the National Institutes of Health, U .S . Public Health Service .

PY - 1979/1/15

Y1 - 1979/1/15

N2 - Immunoreactive vasoactive intestinal polypeptide (VIP) was present in portal hypophyseal blood of 24 male rats in concentrations (mean, 995 pg per ml) that were approximately 19 times as high as those in systemic arterial blood (mean, 52 pg per ml). The results demonstrate release of VIP from the hypothalamic-neurohypophyseal complex into the portal circulation, and establish a mechanism for direct influence of the peptide on pituitary function.

AB - Immunoreactive vasoactive intestinal polypeptide (VIP) was present in portal hypophyseal blood of 24 male rats in concentrations (mean, 995 pg per ml) that were approximately 19 times as high as those in systemic arterial blood (mean, 52 pg per ml). The results demonstrate release of VIP from the hypothalamic-neurohypophyseal complex into the portal circulation, and establish a mechanism for direct influence of the peptide on pituitary function.

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SP - 227

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JO - Life Sciences

JF - Life Sciences

IS - 3

ER -

Vasoactive intestinal polypeptide: Release into hypophyseal portal blood

Abstract

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